Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology · 2004
[Expression of human beta-defensin in palatine tonsil].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Chengshuo, Dong Zhen, Yang Zhanquan
Аннотация
OBJECTIVE: To examine the expression of human beta-defensin-1 (hBD-1) and human beta-defensin-2 (hBD-2) in palatine tonsil of normal subjects and patients with chronic tonsillitis, and to investigate the role of palatine tonsil in the innate immunity system.
METHOD: Eighteen specimens of hyperplastic tonsils (n = 8) and chronic tonsillitis(n = 10) were examined using reverse transcriptase-polymerase chain reaction (RT-PCR).
RESULT: beta-defensin 1 mRNA was expressed in all tissue specimens, at levels that did not differ significantly (P > 0.05). beta-defensin 2 mRNA was detected in the specimens of chronic tonsillitis, but almost not in the normal subjects. Its expression level was significantly higher in chronic inflamed tonsils than in normal controls(P < 0.05).
CONCLUSION: These results suggest that beta-defensin of the palatine tonsil may play an important role in innate defense against microorganisms.
METHOD: Eighteen specimens of hyperplastic tonsils (n = 8) and chronic tonsillitis(n = 10) were examined using reverse transcriptase-polymerase chain reaction (RT-PCR).
RESULT: beta-defensin 1 mRNA was expressed in all tissue specimens, at levels that did not differ significantly (P > 0.05). beta-defensin 2 mRNA was detected in the specimens of chronic tonsillitis, but almost not in the normal subjects. Its expression level was significantly higher in chronic inflamed tonsils than in normal controls(P < 0.05).
CONCLUSION: These results suggest that beta-defensin of the palatine tonsil may play an important role in innate defense against microorganisms.