China CDC weekly · 2026
Putative Adverse Outcome Pathway in Kashin-Beck Disease Suggested by Lipidomics and Network Toxicology - Xi'an City, Shaanxi Province, China, 2023-2025.
СтатьяНазвание и аннотация: Перевод в очереди
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Cui Liangyu, Wang Xi, Wang Chaowei, Liu Yang, Bai Lulu, Liu Lian, Jing Qi, Ma Yuyang, Jiao Pengyan, Chen Zhouyun, Qin Yirong, Wang Hui, Yuan Yuequan, Lyu Xi, Zhang Yu, Guo Xiong, Ning Yujie, Zhang Feng
Аннотация
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Lipids are key mediators in cartilage degeneration. While T-2 toxin exposure drives Kashin-Beck disease (KBD), systematic metabolic comparisons between KBD and osteoarthritis (OA) are lacking.
WHAT IS ADDED BY THIS REPORT?: KBD and OA share cartilage lipid alterations linked to ferroptosis, but KBD exhibits unique changes indicating severe oxidative stress. Furthermore, prostaglandin-endoperoxide synthase 2 (PTGS2) was identified as the candidate molecular target potentially involved in T-2 toxin-induced cartilage damage.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Uncovering the adverse outcome pathway of T-2 toxin exposure clarifies KBD pathogenesis. Targeting the PTGS2-mediated signaling pathway may provide a potential strategy for clinical intervention and disease management.
WHAT IS ADDED BY THIS REPORT?: KBD and OA share cartilage lipid alterations linked to ferroptosis, but KBD exhibits unique changes indicating severe oxidative stress. Furthermore, prostaglandin-endoperoxide synthase 2 (PTGS2) was identified as the candidate molecular target potentially involved in T-2 toxin-induced cartilage damage.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Uncovering the adverse outcome pathway of T-2 toxin exposure clarifies KBD pathogenesis. Targeting the PTGS2-mediated signaling pathway may provide a potential strategy for clinical intervention and disease management.