Neurology open access · 2026
Discordance Between Striatal Dopaminergic Imaging and Motor Performances in REM Sleep Behavior Disorder.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zatti Cinzia, Miyagawa Toji, Kouchache Trycia, Pelletier Amélie, Lowe Val J, Criswell Susan R, Vernon Cynthia J, St Louis Erik K, Fields Julie A, Gagnon Jean-Francois, Kantarci Kejal, Boeve Bradley F, Postuma Ronald
Аннотация
BACKGROUND AND OBJECTIVES: Idiopathic REM sleep behavior disorder (iRBD) is a marker of early neurodegenerative synucleinopathy. Nigrostriatal dopaminergic dysfunction is often considered the primary pathological mechanism behind motor symptoms; however, other mechanisms have been proposed. The study aim was to identify whether there were iRBD patients with a discordance between motor testing and abnormal nigrostriatal uptake, and to characterise those patients.
METHODS: This multicenter study included 108 subjects with polysomnography-confirmed iRBD who underwent [123I]-Ioflupane SPECT (DaT-SPECT) and quantitative motor testing within the same year. Participants were divided into 4 groups (motor slowing/DAT normal, motor normal/DAT positive, both normal, and both abnormal) and were investigated for differences in clinical characteristics. All participants were followed prospectively for a median of 2.5 years.
RESULTS: 43/108 (40%) had discordance between DaT-SPECT and quantitative motor testing, with similar proportion of motor slowing/DAT normal and motor normal/DAT positive participants (n=20 and n=23 respectively). Motor slowing/DAT normal participants had worse MoCA scores (24.9 vs 26.4, p=0.022), a higher frequency of MCI (60% vs 22%, p=0.001), and more autonomic symptoms (SCOPA-AUT=18.7 vs 12.2, p=0.027) compared to the other groups. 3/20 (15%) of the motor slowing/DAT normal group phenoconverted (PD=2, DLB=1), at a median interval of 1.8 years.
DISCUSSION: This study revealed that motor alterations and abnormal nigrostriatal uptake are commonly discordant in iRBD, and that motor abnormalities are common even in those with normal DaT-SPECT. The presence of substantial cognitive and autonomic dysfunction in the motor slowing/DAT normal group suggests a different, likely more diffuse, progression pattern.
METHODS: This multicenter study included 108 subjects with polysomnography-confirmed iRBD who underwent [123I]-Ioflupane SPECT (DaT-SPECT) and quantitative motor testing within the same year. Participants were divided into 4 groups (motor slowing/DAT normal, motor normal/DAT positive, both normal, and both abnormal) and were investigated for differences in clinical characteristics. All participants were followed prospectively for a median of 2.5 years.
RESULTS: 43/108 (40%) had discordance between DaT-SPECT and quantitative motor testing, with similar proportion of motor slowing/DAT normal and motor normal/DAT positive participants (n=20 and n=23 respectively). Motor slowing/DAT normal participants had worse MoCA scores (24.9 vs 26.4, p=0.022), a higher frequency of MCI (60% vs 22%, p=0.001), and more autonomic symptoms (SCOPA-AUT=18.7 vs 12.2, p=0.027) compared to the other groups. 3/20 (15%) of the motor slowing/DAT normal group phenoconverted (PD=2, DLB=1), at a median interval of 1.8 years.
DISCUSSION: This study revealed that motor alterations and abnormal nigrostriatal uptake are commonly discordant in iRBD, and that motor abnormalities are common even in those with normal DaT-SPECT. The presence of substantial cognitive and autonomic dysfunction in the motor slowing/DAT normal group suggests a different, likely more diffuse, progression pattern.