A comparative analysis of the pregnancy outcomes of IVF-ET in postoperative infertile patients with endometriosis treated with platelet-rich plasma and G-CSF: A retrospective cohort study.

This study aimed to investigate the impacts of granulocyte colony-stimulating factor (G-CSF) and platelet-rich plasma (PRP) on the pregnancy outcomes of infertile individuals with endometriosis after in vitro fertilization and embryo transfer (IVF-ET). Patients with endometriosis-induced infertility who underwent elective laparoscopic surgery and IVF-ET were included. They were divided into PRP + IVF-ET, G-CSF + IVF-ET, and control groups. The blood flow typing, endometrial morphology, endometrial thickness, uterine artery blood flow, clinical pregnancy outcomes, and adverse reactions were compared. After treatment, the flow velocity, resistance index, and pulse index of the uterine artery were lower while endometrial thickness was greater in both treatment groups than before treatment (P < .05). After treatment, the proportion of endometrial morphology types A and B was higher while type C was lower than before treatment, and the proportion of endometrial blood flow type I was lower while types II and I-II were higher in both treatment groups (P < .05). Nevertheless, there were no discernible changes in those indexes and adverse reactions between both treatment groups (P > .05). Intrauterine perfusion with either PRP or human G-CSF demonstrated comparable effects in enhancing endometrial receptivity and improving clinical pregnancy outcomes in patients who remained infertile following laparoscopic surgery for endometriosis.