Hormonal Contraceptives: Part II- Use and Relevance in Clinical Dermatology.

Combined oral contraceptives (COC) decrease androgen levels by inhibiting androgen production and increasing sex hormone binding globulin. COC can therefore be used in the treatment of androgen-mediated dermatologic conditions. Hormonal contraceptives may also contribute to some dermatologic diseases through interactions with estrogen and/or progesterone receptors. In part two of this continuing medical education article, we discuss evidence regarding the mechanism and efficacy of hormonal contraceptives as therapeutics for acne, hirsutism, and hair loss, and review potential dermatologic SE of hormonal contraceptives to guide dermatologists in utilizing this therapy in their practices.