Head & neck · 2019
Could the infiltration of the thyroarytenoid muscle define the pT2 glottic carcinoma?
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Lionello Marco, Bertolin Andy, Nardello Ennio, Giacomelli Luciano, Canal Fabio, Rizzotto Giuseppe, Marioni Gino, Lucioni Marco
Аннотация
BACKGROUND: The involvement of the thyroarytenoid (TA) muscle by glottic cancer may be related to an impaired vocal cord mobility, which is classified as cT2 disease. The primary endpoint was to evaluate the prognostic significance of TA muscle involvement in early glottic cancer treated with transoral laser microsurgery (TLM).
METHODS: A review was conducted on a cohort of 209 patients consecutively treated with TLM for early glottic carcinoma. Univariate analysis was used to examine the prognostic meaning of clinical and pathological parameters.
RESULTS: The statistical analysis showed that TA muscle infiltration correlated significantly with a worse prognosis in terms of recurrence rate and disease-free survival, and this was confirmed even in the subcohort with pT1a glottic cancer.
CONCLUSIONS: Our preliminary findings suggest that it could be considered as a criterion for upstaging a glottic cancer from pT1 to pT2.
METHODS: A review was conducted on a cohort of 209 patients consecutively treated with TLM for early glottic carcinoma. Univariate analysis was used to examine the prognostic meaning of clinical and pathological parameters.
RESULTS: The statistical analysis showed that TA muscle infiltration correlated significantly with a worse prognosis in terms of recurrence rate and disease-free survival, and this was confirmed even in the subcohort with pT1a glottic cancer.
CONCLUSIONS: Our preliminary findings suggest that it could be considered as a criterion for upstaging a glottic cancer from pT1 to pT2.
Предметные рубрики MeSH
AgedBiopsy, NeedleCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleGlottisHumansImmunohistochemistryLaryngeal MusclesLaryngeal NeoplasmsLaser TherapyMaleMicrosurgeryMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisRetrospective StudiesSurvival AnalysisTreatment OutcomeVocal Cord Paralysis