Exfoliative dermatitis associated with diltiazem.

BACKGROUND

Exfoliative dermatitis due to calcium channel blockers is a known but infrequent response.

CASE REPORT: A 77-year-old woman began treatment with diltiazem for angina pectoris. Three days later, severe exfoliative dermatitis developed.

CONCLUSION

The present case and the others previously reported emphasize the need for greater awareness of the occurrence of adverse cutaneous reactions including toxic epidermal necrolysis, Stevens-Johnson syndrome and cutaneous vasculitis due to calcium channel blockers including diltiazem.