Uveitis and idiopathic retroperitoneal fibrosis: an unusual association.

Uveitis is a significant cause of visual impairment and is often linked to underlying systemic immune-mediated conditions. Retroperitoneal fibrosis, characterised by the proliferation of fibrotic tissue in the retroperitoneum, can similarly be associated with autoimmune or autoinflammatory diseases. While both conditions have been reported in the context of systemic disorders, their co-occurrence in the absence of a defined systemic diagnosis is exceedingly rare, with only two such cases previously documented.We report the case of a woman in her 30s with a history of idiopathic retroperitoneal fibrosis who later developed recurrent bilateral uveitis. Extensive investigations failed to identify an underlying associated disorder. While a direct aetiological link between the two conditions remains unproven, their coexistence raises the possibility of a shared immune-mediated mechanism. The patient responded favourably to corticosteroids and anti-TNF therapy, further supporting an immune-mediated pathogenesis.