Ocular immunology and inflammation · 2022
Peripheral Ulcerative Keratitis Secondary to the Inactive COVID-19 Vaccine-CoronaVac.
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Penbe Aysegul
Аннотация
PURPOSE: To report a case of peripheral ulcerative keratitis (PUK) secondary to the inactive Covid-19 vaccine.
METHODS: The case of a 67-year-old man who presented with unilateral progressive vision-threatening PUK with nodular scleritis was reported. The results of clinical examinations with surgical and medical treatments were noted.
RESULTS: The extended workup for autoimmune and infectious etiologies for PUK that all returned negative. The patient was treated with oral steroids, azathioprine, and topical cyclosporine with topical dexamethasone for his PUK and underlying possible immunopathology. Corneal amniotic membrane grafting was also performed 4 times and finally, the patient underwent penetrant keratoplasty for visual rehabilitation.
CONCLUSIONS: To our knowledge, we report the first case of PUK that is possible to secondary to an inactive vaccine for SARS-CoV-2. The inactive covid vaccine should be considered as an etiological agent in PUK cases where the standard workup is negative.
METHODS: The case of a 67-year-old man who presented with unilateral progressive vision-threatening PUK with nodular scleritis was reported. The results of clinical examinations with surgical and medical treatments were noted.
RESULTS: The extended workup for autoimmune and infectious etiologies for PUK that all returned negative. The patient was treated with oral steroids, azathioprine, and topical cyclosporine with topical dexamethasone for his PUK and underlying possible immunopathology. Corneal amniotic membrane grafting was also performed 4 times and finally, the patient underwent penetrant keratoplasty for visual rehabilitation.
CONCLUSIONS: To our knowledge, we report the first case of PUK that is possible to secondary to an inactive vaccine for SARS-CoV-2. The inactive covid vaccine should be considered as an etiological agent in PUK cases where the standard workup is negative.