Medicina intensiva · 2026
Effectiveness of silver ion controlled release antimicrobial compound in reducing multi-drug-resistant microorganism contamination in an intensive care unit: An interventional proof-of-concept study.
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Ramirez Paula, Frasquet Juan, Fernandez Sergio, Martínez Héctor, Forteza María, Benamu Esther, Sanchez Trinidad, Arrando Hugo, Garcia-Roig Blanca, González Eva, Castellanos-Ortega Álvaro
Аннотация
OBJECTIVES: Environmental contamination plays a key role in the transmission of multidrug-resistant microorganisms (MDRMs) in intensive care units (ICUs). We evaluated the effectiveness of a silver ion-controlled release antimicrobial compound applied to ICU surfaces in reducing environmental contamination and patient colonization.
DESIGN: Quasi-experimental study with a concurrent control group.
SETTING: A 24-bed ICU divided into two identical subunits.
PARTICIPANTS: All patients admitted to the ICU during the study period.
INTERVENTIONS: One subunit followed standard disinfection procedures (control unit), while the other used standard disinfection plus monthly application of a silver ion-controlled release antimicrobial compound (NOB166®) to high-touch surfaces (intervention unit).
VARIABLES OF INTEREST: Environmental surface cultures and patient surveillance cultures were obtained weekly over a 5-month period.
RESULTS: A total of 506 environmental samples were collected. MDRMs were detected in 22/256 samples (8.5%) from the control unit compared with 8/250 samples (3.2%) from the intervention unit (P = .01). MDRM acquisition occurred in 19/127 patients (14.9%) in the control unit and 10/168 patients (5.9%) in the intervention unit (P < .01). Acinetobacter baumannii and Candida auris were the most frequently isolated organisms. Two MDRM outbreaks occurred in the control unit, whereas none were detected in the intervention unit. Rates of nosocomial infection did not differ significantly between groups.
CONCLUSIONS: The use of a silver ion-controlled release antimicrobial surface coating was associated with a significant reduction in environmental MDRM contamination and patient colonization in ICU. These findings support the role of long-acting antimicrobial surface treatments as adjuncts to standard infection prevention strategies.
DESIGN: Quasi-experimental study with a concurrent control group.
SETTING: A 24-bed ICU divided into two identical subunits.
PARTICIPANTS: All patients admitted to the ICU during the study period.
INTERVENTIONS: One subunit followed standard disinfection procedures (control unit), while the other used standard disinfection plus monthly application of a silver ion-controlled release antimicrobial compound (NOB166®) to high-touch surfaces (intervention unit).
VARIABLES OF INTEREST: Environmental surface cultures and patient surveillance cultures were obtained weekly over a 5-month period.
RESULTS: A total of 506 environmental samples were collected. MDRMs were detected in 22/256 samples (8.5%) from the control unit compared with 8/250 samples (3.2%) from the intervention unit (P = .01). MDRM acquisition occurred in 19/127 patients (14.9%) in the control unit and 10/168 patients (5.9%) in the intervention unit (P < .01). Acinetobacter baumannii and Candida auris were the most frequently isolated organisms. Two MDRM outbreaks occurred in the control unit, whereas none were detected in the intervention unit. Rates of nosocomial infection did not differ significantly between groups.
CONCLUSIONS: The use of a silver ion-controlled release antimicrobial surface coating was associated with a significant reduction in environmental MDRM contamination and patient colonization in ICU. These findings support the role of long-acting antimicrobial surface treatments as adjuncts to standard infection prevention strategies.