Internal medicine (Tokyo, Japan) · 2021
Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Nishiyama Hirono, Tajiri Tomoko, Yamabe Toru, Yasukawa Tsutomu, Takeda Norihisa, Fukumitsu Kensuke, Fukuda Satoshi, Kanemitsu Yoshihiro, Uemura Takehiro, Ohkubo Hirotsugu, Takemura Masaya, Maeno Ken, Ito Yutaka, Oguri Tetsuya, Naniwa Taio, Niimi Akio
Аннотация
Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophilic cytoplasm antibody (ANCA)-associated vasculitis characterized by asthma and eosinophilia. Although EGPA involves multiple organs, ocular involvement is infrequent and often carries a poor visual prognosis. We herein report a rare case of EGPA presenting with central retinal artery occlusion (CRAO) in which visual loss developed during treatment with anti-interleukin (IL)-5 receptor monoclonal antibody, and improvement in visual outcomes was attained after treatment combining high-dose oral corticosteroids, cyclophosphamide and an anticoagulant. Physicians should consider CRAO as an ophthalmic manifestation of EGPA in patients with severe eosinophilic asthma.