Archives of physical medicine and rehabilitation · 2026
Exercise Interventions for Older Adults With Alzheimer Disease: A Systematic Review and Meta-analysis.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Faieta Julie M, Devos Hannes, Philippou Elena, Negm Ahmed, Vaduvathiriyan Prasanna, Erickson Kirk I, Hirsch Mark A, van Wegen Erwin E, Fakorede Sodiq, Dagne Mahederemariam Bayleyegn, Wong Karen Lok Yi, Krishnan Shilpa, Kahya Melike, Sood Pallavi, Heyn Patricia C
Аннотация
OBJECTIVES: Increased Alzheimer disease (AD) prevalence paired with improved ability to diagnose the disease at earlier stages now, more than ever, necessitates interventions that will support the AD population for extended periods of time. Even with the substantial body of literature available, the effectiveness of physical exercise (PE) on various cognitive domains and the optimal dosage of PE are yet to be confirmed. Therefore, our objectives were to determine the effectiveness of PE on cognitive function in older adults with AD and the optimal PE dosage for targeted outcomes.
DATA SOURCES: The search was carried out across Embase, PsycInfo, and Ovid MEDLINE databases.
STUDY SELECTION: Of an initial return of 1001 articles, 142 remained after title and abstract review, and 21 after full-text review.
DATA EXTRACTION: Prabimary outcomes extracted from included articles spanned 4 cognitive domain outcomes (global cognition, memory, language, attention, and executive function). Data on secondary outcomes included activities of daily living, emotional well-being, quality of life, and caregiver burden.
DATA SYNTHESIS: The 21 included studies were published between 1991 and 2020, and sample sizes ranged from 12 to 494. Results confirm significant improvement in 4 of 5 cognitive domains favoring PE versus control conditions. Similarly, results favored exercise over control conditions for activities of daily living, emotional well-being, and quality of life outcomes, but not caregiver burden. The optimal PE dose was determined to be <60 minutes at least 3 times per week as compared with fewer, more intense bouts.
CONCLUSIONS: The results of this systematic review and meta-analysis provide important insight into the effectiveness of exercise on cognitive outcomes and guidance on the most effective PE parameters for optimizing cognitive function in AD.
DATA SOURCES: The search was carried out across Embase, PsycInfo, and Ovid MEDLINE databases.
STUDY SELECTION: Of an initial return of 1001 articles, 142 remained after title and abstract review, and 21 after full-text review.
DATA EXTRACTION: Prabimary outcomes extracted from included articles spanned 4 cognitive domain outcomes (global cognition, memory, language, attention, and executive function). Data on secondary outcomes included activities of daily living, emotional well-being, quality of life, and caregiver burden.
DATA SYNTHESIS: The 21 included studies were published between 1991 and 2020, and sample sizes ranged from 12 to 494. Results confirm significant improvement in 4 of 5 cognitive domains favoring PE versus control conditions. Similarly, results favored exercise over control conditions for activities of daily living, emotional well-being, and quality of life outcomes, but not caregiver burden. The optimal PE dose was determined to be <60 minutes at least 3 times per week as compared with fewer, more intense bouts.
CONCLUSIONS: The results of this systematic review and meta-analysis provide important insight into the effectiveness of exercise on cognitive outcomes and guidance on the most effective PE parameters for optimizing cognitive function in AD.