Annals of nuclear medicine · 2026
[11C]-Methionine PET/CT in evaluation of bone marrow infiltration and usage as a prognostic tool in multiple myeloma.
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Ozkan Elgin, Demir Burak, Seval Guldane Cengiz, Araz Mine, Soydal Cigdem, Mesci Irem, Sonmez Gulcin Miyase, Beksac Meral, Kucuk Nuriye Ozlem
Аннотация
PURPOSE: To evaluate the prognostic utility of a novel quantitative imaging metric, whole-body metabolic burden (WB-MB), derived from [11C]-Methionine PET/CT, in patients with multiple myeloma (MM), and to assess its correlation with clinical biomarkers and survival outcomes.
METHODS: In this prospective, single-center study, 34 patients with biopsy-confirmed MM underwent whole-body [11C]-Methionine PET/CT for staging or restaging. WB-MB was calculated using a semi-quantitative method incorporating both the extent and intensity of methionine uptake across 12 anatomical regions. Liver- and aorta-normalized WB-MB ratios (WB-MB/liver and WB-MB/aorta) were also computed. Correlations with laboratory biomarkers were analyzed using regression models, and prognostic performance was assessed through Kaplan-Meier survival analysis and hazard ratios for progression-free survival (PFS) and overall survival (OS).
RESULTS: WB-MB showed significant inverse correlation with hemoglobin and positive correlations with LDH, beta-2 microglobulin (B2M), and serum kappa free light chain levels. No significant associations were observed with platelet count, WBC, or lambda light chains. WB-MB, WB-MB/liver, and WB-MB/aorta were all significantly associated with OS and PFS (p < 0.05), while maximum SUVmean was not. A WB-MB threshold of 164.79 was identified as predictive for PFS. Notably, no deaths occurred in patients with WB-MB < 101 during follow-up.
CONCLUSION: WB-MB scoring with [11C]-Methionine PET/CT is a promising, reproducible imaging biomarker for evaluating disease burden and prognosis in MM. It correlates with key laboratory markers and outperforms static SUV-based metrics in predicting survival outcomes. Further multicenter studies are needed to validate these findings and explore integration into therapeutic decision-making.
METHODS: In this prospective, single-center study, 34 patients with biopsy-confirmed MM underwent whole-body [11C]-Methionine PET/CT for staging or restaging. WB-MB was calculated using a semi-quantitative method incorporating both the extent and intensity of methionine uptake across 12 anatomical regions. Liver- and aorta-normalized WB-MB ratios (WB-MB/liver and WB-MB/aorta) were also computed. Correlations with laboratory biomarkers were analyzed using regression models, and prognostic performance was assessed through Kaplan-Meier survival analysis and hazard ratios for progression-free survival (PFS) and overall survival (OS).
RESULTS: WB-MB showed significant inverse correlation with hemoglobin and positive correlations with LDH, beta-2 microglobulin (B2M), and serum kappa free light chain levels. No significant associations were observed with platelet count, WBC, or lambda light chains. WB-MB, WB-MB/liver, and WB-MB/aorta were all significantly associated with OS and PFS (p < 0.05), while maximum SUVmean was not. A WB-MB threshold of 164.79 was identified as predictive for PFS. Notably, no deaths occurred in patients with WB-MB < 101 during follow-up.
CONCLUSION: WB-MB scoring with [11C]-Methionine PET/CT is a promising, reproducible imaging biomarker for evaluating disease burden and prognosis in MM. It correlates with key laboratory markers and outperforms static SUV-based metrics in predicting survival outcomes. Further multicenter studies are needed to validate these findings and explore integration into therapeutic decision-making.