Bioinformatics (Oxford, England) · 2026
PangyPlot: multi-scale interactive visualization of pangenome variation graphs.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Mastromatteo Scott, Chirmade Shalvi, Roshandel Delnaz, Thiruvahindrapuram Bhooma, Wang Zhuozhi, Patel Rohan V, Sung Wilson W L, Hajianpour Amirhossein, Wang Cheng, Lin Fan, Keenan Katherine, Avolio Julie, Eckford Paul D W, Ratjen Felix, Canadian Cystic Fibrosis Gene Modifier Consortium, Strug Lisa J
Аннотация
SUMMARY: Pangenome variation graphs integrate multiple samples into a unified representation, mitigating the reference bias inherent to linear genomes. However, these graphs can be large and structurally complex. Existing visualization tools are each confined to a fixed scale of resolution, requiring researchers to switch between multiple tools to examine variation at different levels of detail. PangyPlot is an interactive pangenome browser designed for multi-scale exploration of reference variation graphs from full chromosome to nucleotide-level sequence segments. PangyPlot anchors navigation to linear reference coordinates, organizes variation into hierarchical bubble structures, and uses a force-directed layout engine for automatic node arrangement.
AVAILABILITY AND IMPLEMENTATION: An instance preloaded with data is available at https://pangyplot.research.sickkids.ca. Source code and documentation are openly available at https://github.com/strug-hub/pangyplot under the MIT License.
AVAILABILITY AND IMPLEMENTATION: An instance preloaded with data is available at https://pangyplot.research.sickkids.ca. Source code and documentation are openly available at https://github.com/strug-hub/pangyplot under the MIT License.