The Nigerian postgraduate medical journal · 2025
Monitoring of Helicobacter pylori Infection in Dyspeptic Adults Based on Histopathological, Endoscopic and Urea Breath Tests in Karbala City.
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Al-Mosawi Fatin Hasim, Al-Ali Zainab A, Hasan Farah Falah, Al-Janabi Ali Abdul Hussein S
Аннотация
BACKGROUND: Accurate detection of Helicobacter pylori infection is crucial for properly treating patients with dyspepsia. Several invasive and non-invasive diagnostic methods are being utilised.
AIMS: This study aimed to determine the prevalence of H. pylori in adult patients with dyspeptic conditions and how it related to endoscopic findings, histological features and the relationship to urea breath test (UBT) results.
METHODS: From 723, 100 adult dyspeptic outpatients who underwent UBT and endoscopy were investigated at the Department of Gastroenterology in Imam Al-Hujjah Hospital for gastroduodenal biopsy. A histopathological study was also used to identify H. pylori.
RESULTS: The study included 68 females (37 H. pylori positive and 31 with H. pylori negative) and 32 males (13 with H. pylori and 19 without H. pylori) with a female-to-male ratio of 2.1:1. The most common endoscopic finding was nodularity in 28 patients (46%) H. pylori positive and 5 (10%) H. pylori negative, followed by gastritis, erosive gastritis, erythema, hiatus hernia and gastric ulcer. The most common histological feature was chronic gastritis in 52 cases (64%) in the positive bacterial cases and 20 (36%) in the negative group, with a statistically significant relationship. There was a significant difference between histopathological findings with both endoscopic examination and UBT results for H. pylori positive and negative patients.
CONCLUSIONS: Endoscopic and histological studies with UBT showed a significant ability to detect H. pylori. Early detection and treatment are crucial for the H. pylori infection to avoid major complications.
AIMS: This study aimed to determine the prevalence of H. pylori in adult patients with dyspeptic conditions and how it related to endoscopic findings, histological features and the relationship to urea breath test (UBT) results.
METHODS: From 723, 100 adult dyspeptic outpatients who underwent UBT and endoscopy were investigated at the Department of Gastroenterology in Imam Al-Hujjah Hospital for gastroduodenal biopsy. A histopathological study was also used to identify H. pylori.
RESULTS: The study included 68 females (37 H. pylori positive and 31 with H. pylori negative) and 32 males (13 with H. pylori and 19 without H. pylori) with a female-to-male ratio of 2.1:1. The most common endoscopic finding was nodularity in 28 patients (46%) H. pylori positive and 5 (10%) H. pylori negative, followed by gastritis, erosive gastritis, erythema, hiatus hernia and gastric ulcer. The most common histological feature was chronic gastritis in 52 cases (64%) in the positive bacterial cases and 20 (36%) in the negative group, with a statistically significant relationship. There was a significant difference between histopathological findings with both endoscopic examination and UBT results for H. pylori positive and negative patients.
CONCLUSIONS: Endoscopic and histological studies with UBT showed a significant ability to detect H. pylori. Early detection and treatment are crucial for the H. pylori infection to avoid major complications.