Resuscitation · 2025
Obesity and nutrition risk in patients admitted to intensive care after cardiac arrest: A multicentre cohort study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Lim Shir Lynn, Ling Ryan Ruiyang, Lim Oliver, Ueno Ryo, Jones Daryl, Low Christopher, Ong Marcus E H, Ridley Emma J, Sundararajan Krishnaswamy, Pilcher David, Ramanathan Kollengode, Subramaniam Ashwin
Аннотация
BACKGROUND: The double burden of malnutrition, defined as the co-existence of overnutrition with undernutrition, is increasing in prevalence globally. Yet, little is known about its impact on patients with cardiac arrest. We examined the association between malnutrition and outcomes in patients admitted to intensive care units (ICU) after cardiac arrest.
METHODS: In this retrospective cohort study, we included adults admitted to ICU in Australia or New Zealand between 1/1/2018 through 31/3/2023 who had suffered a cardiac arrest in the 24 h prior to admission. We categorized patients based on the presence of obesity (BMI ≥ 30 kg/m2) and nutrition risk (using the modified Nutrition Risk in Critically ill score ≥5) and investigated the association between obesity and high nutrition risk with survival time up to 1 year, adjusting for a prespecified list of covariates. We also analysed this association in specific subgroups (age <65 years vs ≥65 years, location of arrest, frailty status, sex, and in patients who survived their initial hospitalisation).
RESULTS: We included 12,565 patients with a median age of 62.4 (IQR: 49.4-72.8) years and 8426 (67.1 %) males; 4088 (32.5 %) were neither obese nor at high nutrition risk, 2170 (17.3 %) had obesity, 4001 (31.8 %) had high nutrition risk, and 2306 (18.4 %) were both obese and high nutrition risk. Compared to patients with neither obesity nor high nutrition risk, obesity combined with high nutrition risk (HR: 1.61, 95 %-CI: 1.40-1.85) and high nutrition risk alone (HR: 1.66, 95 %-CI: 1.47-1.87) were associated with reductions in survival time. However, obesity alone (HR: 0.93, 95 %-CI: 0.83-1.03) was not associated with a significant difference in survival time. These results were consistent across subgroups.
CONCLUSION: Among resuscitated cardiac arrest patients admitted to ICU, high nutrition risk is prevalent regardless of obesity status and is associated with poorer outcomes in-hospital and up to one year. More research is needed to identify mitigating strategies for malnourished patients.
METHODS: In this retrospective cohort study, we included adults admitted to ICU in Australia or New Zealand between 1/1/2018 through 31/3/2023 who had suffered a cardiac arrest in the 24 h prior to admission. We categorized patients based on the presence of obesity (BMI ≥ 30 kg/m2) and nutrition risk (using the modified Nutrition Risk in Critically ill score ≥5) and investigated the association between obesity and high nutrition risk with survival time up to 1 year, adjusting for a prespecified list of covariates. We also analysed this association in specific subgroups (age <65 years vs ≥65 years, location of arrest, frailty status, sex, and in patients who survived their initial hospitalisation).
RESULTS: We included 12,565 patients with a median age of 62.4 (IQR: 49.4-72.8) years and 8426 (67.1 %) males; 4088 (32.5 %) were neither obese nor at high nutrition risk, 2170 (17.3 %) had obesity, 4001 (31.8 %) had high nutrition risk, and 2306 (18.4 %) were both obese and high nutrition risk. Compared to patients with neither obesity nor high nutrition risk, obesity combined with high nutrition risk (HR: 1.61, 95 %-CI: 1.40-1.85) and high nutrition risk alone (HR: 1.66, 95 %-CI: 1.47-1.87) were associated with reductions in survival time. However, obesity alone (HR: 0.93, 95 %-CI: 0.83-1.03) was not associated with a significant difference in survival time. These results were consistent across subgroups.
CONCLUSION: Among resuscitated cardiac arrest patients admitted to ICU, high nutrition risk is prevalent regardless of obesity status and is associated with poorer outcomes in-hospital and up to one year. More research is needed to identify mitigating strategies for malnourished patients.