Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion · 2026
The risk of Metabolic Dysfunction-Associated Steatotic Liver Disease in patients with psoriasis: An updated systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
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Nie Hongwei, Yang Long, Zhong Huali, Zhang Ying, Wang Mingyue
Аннотация
AIM: The aim of this study is to evaluate the correlation between psoriasis and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). This provides an important reference for formulating guidelines for the management of psoriasis comorbidities and improving the long-term prognosis of patients.
METHODS: A systematic search was conducted across four databases: PubMed, Web of Science, Embase, and the Cochrane Library, covering the period from their inception to November 2025. A meta-analysis employing random-effects model (DerSimonian-Laird method) was conducted to assess the association between MASLD in psoriatic and non-psoriatic patients. Subgroup analyses were performed for psoriatic arthritis (PsA) and patients with moderate-to-severe psoriasis.
RESULTS: This review included 13 studies comprising 6 case-control studies, 3 cohort studies, and 4 cross-sectional studies. Meta-analysis results indicated that individuals with psoriasis exhibited an increased risk of MASLD compared to those without psoriasis (OR=2.16, 95% CI: 1.65-2.83). Further subgroup analysis revealed that patients with moderate to severe psoriasis exhibited a heightened risk of MASLD compared to those with mild psoriasis (OR=2.81, 95% CI: 1.62-4.86). Additionally, the risk of MASLD among patients with PsA was not statistically significant (OR=1.48, 95% CI: 0.69-3.19).
CONCLUSION: There is an association between psoriasis and MASLD, and patients with moderate to severe psoriasis have a higher risk of MASLD. Current evidence does not show a clear association between PsA and MASLD, but this conclusion is limited by the small number of included studies and requires further validation. This study provides a reference basis for formulating guidelines for the management of comorbidities in psoriasis, but it should be interpreted with caution due to the inherent limitations of observational studies.
METHODS: A systematic search was conducted across four databases: PubMed, Web of Science, Embase, and the Cochrane Library, covering the period from their inception to November 2025. A meta-analysis employing random-effects model (DerSimonian-Laird method) was conducted to assess the association between MASLD in psoriatic and non-psoriatic patients. Subgroup analyses were performed for psoriatic arthritis (PsA) and patients with moderate-to-severe psoriasis.
RESULTS: This review included 13 studies comprising 6 case-control studies, 3 cohort studies, and 4 cross-sectional studies. Meta-analysis results indicated that individuals with psoriasis exhibited an increased risk of MASLD compared to those without psoriasis (OR=2.16, 95% CI: 1.65-2.83). Further subgroup analysis revealed that patients with moderate to severe psoriasis exhibited a heightened risk of MASLD compared to those with mild psoriasis (OR=2.81, 95% CI: 1.62-4.86). Additionally, the risk of MASLD among patients with PsA was not statistically significant (OR=1.48, 95% CI: 0.69-3.19).
CONCLUSION: There is an association between psoriasis and MASLD, and patients with moderate to severe psoriasis have a higher risk of MASLD. Current evidence does not show a clear association between PsA and MASLD, but this conclusion is limited by the small number of included studies and requires further validation. This study provides a reference basis for formulating guidelines for the management of comorbidities in psoriasis, but it should be interpreted with caution due to the inherent limitations of observational studies.