Internal medicine (Tokyo, Japan) · 2020
Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined with Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Takahashi Mari, Horio Yukihiro, Takihara Takahisa, Enokida Keito, Miyaoka Masashi, Hirabayashi Kenichi, Ohshinden Kana, Hattori Shigeaki, Takahashi Fuminari, Takahashi Genki, Tanaka Jun, Takiguchi Hiroto, Niimi Kyoko, Ito Yoko, Hayama Naoki, Oguma Tsuyoshi, Asano Koichiro
Аннотация
A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis. A nodule with a diameter of 19 mm was found in the right lung and diagnosed as lung squamous cell carcinoma. Anti-cancer treatments were not performed because of the presence of advanced interstitial pneumonia and chronic respiratory failure. Cyclosporine A was tapered to avoid suppression of anti-tumor immunity, and pirfenidone was initiated. Within 2 months, the tumor had shrunk to 10 mm in diameter and remained regressed for 9 months. This is the first report of a non-hematologic solid organ tumor responding to the discontinuation of immunosuppressants.