BMC infectious diseases · 2026
Prevalence and phenotypic characterization of carbapenem resistance in multidrug-resistant Gram-negative bacteria across selected healthcare facilities in the United Arab Emirates: a retrospective study.
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Aljaede Rula A M, Beshir Semira Abdi, Jaber Ammar Ali Saleh, Elkalmi Ramadan, Ali Eiman Shamseldin Al Gailani, Khedr Amany Hamed Mahmoud, ALHamed Dujana, Meera Jainamboo, AlDeesi Zulfa
Аннотация
BACKGROUND: Carbapenems are essential antibiotics used to treat severe nosocomial infections. However, the misuse of these antibiotics has led to the emergence of carbapenem-resistant organisms (CROs), posing significant public health threats. This study aims to determine the prevalence and phenotypic profile of carbapenem resistance (CR) in multidrug-resistant Gram-negative bacteria (MDR-GNB) in selected healthcare facilities in the United Arab Emirates (UAE).
METHODS: A retrospective study was conducted across 65 healthcare facilities in Dubai and the Northern Emirates (NE) from January 2018 to June 2021. Results from GNB isolates - including Enterobacterales, Acinetobacter, and Pseudomonas aeruginosa- obtained from various clinical samples were collected and assessed for CR using CLSI guidelines at all locations. MDR-CRO prevalence was calculated within each bacterial group using total isolates of that group as the denominator at each time point.
RESULTS: Of the 77,228 GNB collected, 3,829 (5%) MDR-CROs were identified. Within the MDR-CROs subset, Enterobacterales accounted for 65.8% (48.7% of which were Klebsiella pneumoniae), P. aeruginosa 28.6%, and Acinetobacter 5.6%. In contrast, period prevalence calculated within total isolates of each organism group was highest for MDR-CR Acinetobacter (22.8%), followed by MDR-CR P. aeruginosa (12.9%), and MDR-CR Enterobacterales (5.6%). A significant increase in MDR-CR Acinetobacter was observed in the NE in mid-2021, which coincided with the COVID-19 pandemic. Hospitals were the primary source of MDR-CR isolates, accounting for more than 90% of Acinetobacter and P. aeruginosa cases, and 62.6% of Enterobacterales cases. Carbapenems nonsusceptibility varied among bacterial species.
CONCLUSIONS: This study highlights the increasing CR burden of Acinetobacter, P. aeruginosa, and K. pneumoniae in the UAE. Regional variations in resistance, particularly the MDR-CR Acinetobacter surge in the NE during the COVID-19 pandemic, stress the need for tailored infection control measures and antimicrobial stewardship.
METHODS: A retrospective study was conducted across 65 healthcare facilities in Dubai and the Northern Emirates (NE) from January 2018 to June 2021. Results from GNB isolates - including Enterobacterales, Acinetobacter, and Pseudomonas aeruginosa- obtained from various clinical samples were collected and assessed for CR using CLSI guidelines at all locations. MDR-CRO prevalence was calculated within each bacterial group using total isolates of that group as the denominator at each time point.
RESULTS: Of the 77,228 GNB collected, 3,829 (5%) MDR-CROs were identified. Within the MDR-CROs subset, Enterobacterales accounted for 65.8% (48.7% of which were Klebsiella pneumoniae), P. aeruginosa 28.6%, and Acinetobacter 5.6%. In contrast, period prevalence calculated within total isolates of each organism group was highest for MDR-CR Acinetobacter (22.8%), followed by MDR-CR P. aeruginosa (12.9%), and MDR-CR Enterobacterales (5.6%). A significant increase in MDR-CR Acinetobacter was observed in the NE in mid-2021, which coincided with the COVID-19 pandemic. Hospitals were the primary source of MDR-CR isolates, accounting for more than 90% of Acinetobacter and P. aeruginosa cases, and 62.6% of Enterobacterales cases. Carbapenems nonsusceptibility varied among bacterial species.
CONCLUSIONS: This study highlights the increasing CR burden of Acinetobacter, P. aeruginosa, and K. pneumoniae in the UAE. Regional variations in resistance, particularly the MDR-CR Acinetobacter surge in the NE during the COVID-19 pandemic, stress the need for tailored infection control measures and antimicrobial stewardship.