Journal of neurovirology · 2017
Neurological and multiple organ involvement due to Paracoccidioides brasiliensis and HIV co-infection diagnosed at autopsy.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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de Almeida Sergio Monteiro, Roza Thiago H, Salvador Gabriel L O, França João C B, Vidal Luine Rosele Renaud, Nogueira Meri Bordignon, Oliva Lubomira Veronica, Torres Luis Fernando Bleggi, de Noronha Lucia Helena
Аннотация
Paracoccidioidomycosis (PCM), caused by Paracoccidioides brasiliensis, is the most prevalent systemic mycosis among immunocompetent patients in Latin America; it is rare in immunocompromised patients. The estimated frequency of central nervous system (CNS) involvement in the HIV/PCM population was 2.5%. We report a case of HIV/P. brasiliensis co-infection, with neurological (NPCM) and multiple organ involvement, indicating a diagnosis of AIDS. PCM diagnosis was established during the autopsy. This is the first described case of HIV/P. brasiliensis co-infection with CNS involvement diagnosed at autopsy. In conclusion, the diagnosis of NPCM is challenging, and it must be considered in the differential diagnosis in HIV-positive patients who reside in or have visited areas in which the condition is endemic and who present with neurological symptoms.