Cancer causes & control : CCC · 2026
Second primary cancers among females with a first primary cervical, uterine and ovarian cancer: a population-based study in North Portugal.
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Gonçalves Elisabete, Fontes Filipa, Rodrigues Jéssica Rocha, Calisto Rita, Bento Maria José, Lunet Nuno, Morais Samantha
Аннотация
PURPOSE: To estimate the incidence rates of second primary cancers (SCPs) [diagnosed > 2 months after a first primary cancer (FPC)], and cumulative incidence and mortality of metachronous SPCs in patients with a cervical, uterine, or ovarian FPC, and to compare the incidence of SPCs with that expected in the general female population.
METHODS: A cohort of patients with cervical, uterine, or ovarian FPC from the North Region Cancer Registry of Portugal, diagnosed in 2000-2010 (n = 5846) was followed until 31/12/2015 for synchronous and metachronous SPCs. Cumulative incidence of metachronous SPCs considering death as a competing event, and incidence rates and standardized incidence ratios (SIR) of SPCs were estimated.
RESULTS: Diagnosis of an SPC occurred in 541 (9.3%) patients at a median age of 60 years. SPCs were more frequent among patients with uterine cancers. Colon, breast, and corpus uteri were the most common sites for an SPC among patients with a gynecological FPC. A higher incidence of all and individual SPCs compared to the general female population was found (SIR = 1.96, 95% CI 1.79-2.12) with the most relevant sites being cancers of the colon (SIR = 2.32, 95% CI 1.82-2.89), lung (SIR = 2.70, 95% CI 1.88, 3.66), cervix (SIR = 4.87, 95% CI 3.43, 6.56), corpus uteri (SIR = 5.37, 95% CI 4.16, 6.73) and ovary (SIR = 6.06, 95% CI 4.12-8.37). The 10-year cumulative incidence of a metachronous SPC and death for patients with a gynecological FPC was 7.4% and 39.2%, respectively.
CONCLUSION: In Portugal, patients with a gynecological FPC have a higher incidence of SPCs compared to the general female population, particularly elderly females. Increased surveillance and counselling among these patients are needed.
METHODS: A cohort of patients with cervical, uterine, or ovarian FPC from the North Region Cancer Registry of Portugal, diagnosed in 2000-2010 (n = 5846) was followed until 31/12/2015 for synchronous and metachronous SPCs. Cumulative incidence of metachronous SPCs considering death as a competing event, and incidence rates and standardized incidence ratios (SIR) of SPCs were estimated.
RESULTS: Diagnosis of an SPC occurred in 541 (9.3%) patients at a median age of 60 years. SPCs were more frequent among patients with uterine cancers. Colon, breast, and corpus uteri were the most common sites for an SPC among patients with a gynecological FPC. A higher incidence of all and individual SPCs compared to the general female population was found (SIR = 1.96, 95% CI 1.79-2.12) with the most relevant sites being cancers of the colon (SIR = 2.32, 95% CI 1.82-2.89), lung (SIR = 2.70, 95% CI 1.88, 3.66), cervix (SIR = 4.87, 95% CI 3.43, 6.56), corpus uteri (SIR = 5.37, 95% CI 4.16, 6.73) and ovary (SIR = 6.06, 95% CI 4.12-8.37). The 10-year cumulative incidence of a metachronous SPC and death for patients with a gynecological FPC was 7.4% and 39.2%, respectively.
CONCLUSION: In Portugal, patients with a gynecological FPC have a higher incidence of SPCs compared to the general female population, particularly elderly females. Increased surveillance and counselling among these patients are needed.