Current opinion in supportive and palliative care · 2026
Sensory neuron heterogeneity in neuropathic pain: implications for precision analgesia.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Haag Natja, Körner Jannis
Аннотация
PURPOSE OF REVIEW: Neuropathic pain remains a major clinical challenge, with limited mechanism-based treatment options. This review summarizes recent advances in sensory neuron biology, with a particular focus on the transcriptomic and functional heterogeneity of nociceptive neurons and their implications for precision analgesic development.
RECENT FINDINGS: Single-cell transcriptomics and multimodal approaches have revealed previously unrecognized sensory neuron diversity and dynamic state-dependent plasticity. Recent human dorsal root ganglion (DRG) atlases and Patch-seq studies have further demonstrated that neuronal identity arises from the interaction between transcriptional state and functional phenotype, thereby uncovering pain-relevant neuronal subtypes and novel therapeutic targets.
SUMMARY: Sensory neurons emerge as transcriptionally diverse and dynamically regulated cellular states, rather than fixed neuronal classes. Recent advances in single-cell transcriptomics and multimodal profiling are refining our understanding of sensory neuron heterogeneity and providing new opportunities for mechanism-based therapeutic development in neuropathic pain.
RECENT FINDINGS: Single-cell transcriptomics and multimodal approaches have revealed previously unrecognized sensory neuron diversity and dynamic state-dependent plasticity. Recent human dorsal root ganglion (DRG) atlases and Patch-seq studies have further demonstrated that neuronal identity arises from the interaction between transcriptional state and functional phenotype, thereby uncovering pain-relevant neuronal subtypes and novel therapeutic targets.
SUMMARY: Sensory neurons emerge as transcriptionally diverse and dynamically regulated cellular states, rather than fixed neuronal classes. Recent advances in single-cell transcriptomics and multimodal profiling are refining our understanding of sensory neuron heterogeneity and providing new opportunities for mechanism-based therapeutic development in neuropathic pain.