Alimentary pharmacology & therapeutics · 2007
Review article: The relevance of surveillance endoscopy in long-lasting inflammatory bowel disease.
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Vleggaar F P, Lutgens M W M D, Claessen M M H
Аннотация
BACKGROUND: Development of colitis-associated colorectal cancer is an important clinical problem in patients with colonic inflammatory bowel disease (IBD). British and American guidelines recommend to start surveillance after a disease duration of 8-10 or 15-20 years for patients with extensive or left-sided colitis, respectively.
AIM: To assess the evidence level of current surveillance strategies.
METHODS: A PubMed-based literature search using the search terms inflammatory bowel disease, ulcerative colitis, Crohn's disease, dysplasia, colorectal cancer and surveillance was performed.
RESULTS: Low-grade and high-grade dysplastic lesions progress to cancer in a high percentage of patients. Furthermore, concurrent cancer is found in approximately one-third of the patients with colonic dysplasia. Low-level evidence showing reduced colorectal cancer-related mortality in patients who were undergoing surveillance is available. Patients with concomitant primary sclerosing cholangitis form a subgroup of IBD patients with an even higher risk of colorectal neoplasia.
CONCLUSIONS: Colonic surveillance prolongs life expectancy of patients with long-lasting IBD.
AIM: To assess the evidence level of current surveillance strategies.
METHODS: A PubMed-based literature search using the search terms inflammatory bowel disease, ulcerative colitis, Crohn's disease, dysplasia, colorectal cancer and surveillance was performed.
RESULTS: Low-grade and high-grade dysplastic lesions progress to cancer in a high percentage of patients. Furthermore, concurrent cancer is found in approximately one-third of the patients with colonic dysplasia. Low-level evidence showing reduced colorectal cancer-related mortality in patients who were undergoing surveillance is available. Patients with concomitant primary sclerosing cholangitis form a subgroup of IBD patients with an even higher risk of colorectal neoplasia.
CONCLUSIONS: Colonic surveillance prolongs life expectancy of patients with long-lasting IBD.