Photodiagnosis and photodynamic therapy · 2026
Geographic, polygonal, light-brown scales and fluorescent bright-blue margins: Characteristic dermoscopic clues for granular parakeratosis.
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Zhang Qi, Sun Jianfang, Wang Xiaopo
Аннотация
BACKGROUND: Granular parakeratosis (GP) is an uncommon dermatosis characterized by scaly, erythematous to brownish eruptions in intertriginous areas. Diagnosis is challenging and traditionally requires histological confirmation. While dermoscopy and ultraviolet-induced fluorescence dermoscopy (UVFD) offer non-invasive diagnostic approaches, their characteristic findings in GP remain inadequately defined.
OBJECTIVE: This study aimed to systematically characterize the dermoscopic and UVFD features of GP, with a secondary aim of evaluating their diagnostic utility in differentiating GP from other intertriginous dermatoses.
METHODS: We retrospectively analyzed 21 patients with clinicopathologically confirmed GP. Dermoscopic and UVFD data from patients with inverse psoriasis (n = 10), tinea cruris (n = 23), and erythrasma (n = 12) were collected for comparison. Parameters included background color, vascular morphology and distribution, scale color and distribution, and UVFD fluorescence.
RESULTS: Among 21 GP patients (male: female 13:8; mean age 38.4 ± 15.2 years), 71.4% reported prior exposure to disinfectants containing benzalkonium chloride. Symmetrical, erythematous to brown patches/plaques with variable scaling were observed, predominantly in axillae (61.9%), with pruritus /burning in 71.4%. Dermoscopy revealed large, geographic, polygonal, light-brown scales. Under UVFD, 81% of GP exhibited bright-blue margins. Comparative analysis distinguished GP from inverse psoriasis (uniform red background with regular vessels), tinea cruris (peripheral scaling and distinct vascular patterns), and erythrasma (coral-red fluorescence under UVFD, also seen in 60.0% of inverse psoriasis cases).
CONCLUSION: Dermoscopy and UVFD provide reliable, non-invasive diagnostic clues for the GP. The presence of light-brown geographic scales and fluorescent bright-blue margins offers a practical, non-invasive tool for accurate GP diagnosis.
OBJECTIVE: This study aimed to systematically characterize the dermoscopic and UVFD features of GP, with a secondary aim of evaluating their diagnostic utility in differentiating GP from other intertriginous dermatoses.
METHODS: We retrospectively analyzed 21 patients with clinicopathologically confirmed GP. Dermoscopic and UVFD data from patients with inverse psoriasis (n = 10), tinea cruris (n = 23), and erythrasma (n = 12) were collected for comparison. Parameters included background color, vascular morphology and distribution, scale color and distribution, and UVFD fluorescence.
RESULTS: Among 21 GP patients (male: female 13:8; mean age 38.4 ± 15.2 years), 71.4% reported prior exposure to disinfectants containing benzalkonium chloride. Symmetrical, erythematous to brown patches/plaques with variable scaling were observed, predominantly in axillae (61.9%), with pruritus /burning in 71.4%. Dermoscopy revealed large, geographic, polygonal, light-brown scales. Under UVFD, 81% of GP exhibited bright-blue margins. Comparative analysis distinguished GP from inverse psoriasis (uniform red background with regular vessels), tinea cruris (peripheral scaling and distinct vascular patterns), and erythrasma (coral-red fluorescence under UVFD, also seen in 60.0% of inverse psoriasis cases).
CONCLUSION: Dermoscopy and UVFD provide reliable, non-invasive diagnostic clues for the GP. The presence of light-brown geographic scales and fluorescent bright-blue margins offers a practical, non-invasive tool for accurate GP diagnosis.