Obesity (Silver Spring, Md.) · 2026
Virtual Weight Management and Continuous Glucose Monitoring in Patients With Type 2 Diabetes: A Randomized Controlled Trial.
СтатьяМногоцентровое исследованиеРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Katzmarzyk Peter T, Drews Kimberly, Ard Jamy D, McLaughlin Tracey L, Harris Melissa N, Lee Alexandra, Foster Gary D, Lee Hyun Jung, Dunn Timothy C, Martin Corby K, Greenway Frank L, Cardel Michelle I
Аннотация
OBJECTIVE: This study examined the effectiveness of behavioral weight management integrated with continuous glucose monitoring (CGM) among adults with overweight or obesity and type 2 diabetes.
METHODS: This was a two-arm, parallel, randomized clinical trial. Participants (n = 151) were randomly assigned to intervention (INT; n = 75) or usual care (UC; N = 76). INT participants received a behavioral weight management program tailored for type 2 diabetes and CGM. UC participants received a session with a dietitian and educational materials. The primary outcome was 6-month change in HbA1c%. Additional outcomes included changes in weight, waist circumference, blood pressure, CGM metrics, diabetes stress, and treatment satisfaction.
RESULTS: INT reduced HbA1c% (-0.87%; 95% CI: -1.17%, -0.57%) more than UC (-0.41%; -0.72%, -0.10%) (difference: -0.46%; -0.89%, -0.03%; p = 0.037). INT had greater reductions in percent body weight compared to UC (difference: -3.2%; -4.9%, -1.5%; p < 0.001). Several CGM metrics improved significantly more in INT than UC, and INT had significantly greater improvements in diabetes treatment satisfaction and regimen-related diabetes stress relative to UC.
CONCLUSIONS: Integrating CGM with a digital weight management program produced significantly greater improvements in HbA1c%, body weight, and other glucose metrics compared to UC among adults with overweight or obesity and type 2 diabetes.
TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT05935514.
METHODS: This was a two-arm, parallel, randomized clinical trial. Participants (n = 151) were randomly assigned to intervention (INT; n = 75) or usual care (UC; N = 76). INT participants received a behavioral weight management program tailored for type 2 diabetes and CGM. UC participants received a session with a dietitian and educational materials. The primary outcome was 6-month change in HbA1c%. Additional outcomes included changes in weight, waist circumference, blood pressure, CGM metrics, diabetes stress, and treatment satisfaction.
RESULTS: INT reduced HbA1c% (-0.87%; 95% CI: -1.17%, -0.57%) more than UC (-0.41%; -0.72%, -0.10%) (difference: -0.46%; -0.89%, -0.03%; p = 0.037). INT had greater reductions in percent body weight compared to UC (difference: -3.2%; -4.9%, -1.5%; p < 0.001). Several CGM metrics improved significantly more in INT than UC, and INT had significantly greater improvements in diabetes treatment satisfaction and regimen-related diabetes stress relative to UC.
CONCLUSIONS: Integrating CGM with a digital weight management program produced significantly greater improvements in HbA1c%, body weight, and other glucose metrics compared to UC among adults with overweight or obesity and type 2 diabetes.
TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT05935514.