Indian journal of pediatrics · 2025
Clinicoepidemiological Characteristics of Recurrent Intussusception Among Children Younger than 2 Years Hospitalized in Four States in Southern and Western India.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Chaudhary Varsha Sudhir, Machathi Anupama, Kharat Namrata, Premkumar Prasanna Samuel, Lingam Ragavi, Kannan Poovarasan, Mohan Venkata Raghava
Аннотация
OBJECTIVES: To assess the incidence of recurrent episodes of intussusception in children in southern and western India and identify risk factors associated with recurrence.
METHODS: This multicenter observational study was conducted from August 2019 to December 2022 in children with intussusception aged under 2 y admitted to 21 hospitals in four Indian states: Kerala and Karnataka in southern India and Maharashtra and Gujarat in western India. Clinical, epidemiological, and sociodemographic data were collected using structured questionnaires, medical records, and radiological reports. A single follow-up was conducted in July 2023 to assess vital status and the incidence of intussusception recurrence.
RESULTS: Out of the 1,406 children enrolled with intussusception, 85 were unavailable for follow-up and 55 (4.2%) experienced one or more recurrent episodes during the study period. The median time to the first recurrence was 137 d. The incidence of recurrence was significantly higher in Kerala (40/697; 5.7%) than in the other three states (15/624; 2.4%; p = 0.027). Incessant crying and irritability were significantly more common in recurrent episodes (20/55; 36.4%) than in first episodes (269/1,266; 21.2%; p = 0.009). Radiological reduction was significantly more common in recurrent cases (49/55; 89.1%) than in first-episode cases (988/1,266; 78%; p = 0.039).
CONCLUSIONS: This study reveals regional and clinical factors associated with recurrence of intussusception and highlights the need for region-specific protocols to optimize treatment and minimize the incidence of recurrence. The reasons for the regional disparities in the incidence of recurrence should be investigated.
METHODS: This multicenter observational study was conducted from August 2019 to December 2022 in children with intussusception aged under 2 y admitted to 21 hospitals in four Indian states: Kerala and Karnataka in southern India and Maharashtra and Gujarat in western India. Clinical, epidemiological, and sociodemographic data were collected using structured questionnaires, medical records, and radiological reports. A single follow-up was conducted in July 2023 to assess vital status and the incidence of intussusception recurrence.
RESULTS: Out of the 1,406 children enrolled with intussusception, 85 were unavailable for follow-up and 55 (4.2%) experienced one or more recurrent episodes during the study period. The median time to the first recurrence was 137 d. The incidence of recurrence was significantly higher in Kerala (40/697; 5.7%) than in the other three states (15/624; 2.4%; p = 0.027). Incessant crying and irritability were significantly more common in recurrent episodes (20/55; 36.4%) than in first episodes (269/1,266; 21.2%; p = 0.009). Radiological reduction was significantly more common in recurrent cases (49/55; 89.1%) than in first-episode cases (988/1,266; 78%; p = 0.039).
CONCLUSIONS: This study reveals regional and clinical factors associated with recurrence of intussusception and highlights the need for region-specific protocols to optimize treatment and minimize the incidence of recurrence. The reasons for the regional disparities in the incidence of recurrence should be investigated.