Psychiatria polska · 2004
[Use of high-dose olanzapine for treatment of acute relapse of schizophrenia in a patient with bad tolerance of typical neuroleptics. Case report].
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Niedoborek Arkadiusz, Wójcicka Anna
Аннотация
AIM: The purpose of the study was to assess the efficacy of high doses of olanzapine for treatment of the patient suffering from schizophrenia with predominance of positive symptoms. The blood levels of prolactin and glucose were monitored in order to determine the influence of high dose of olanzapine on these levels and to make a comparison between olanzapine and typical neuroleptics in this aspect.
METHOD: The patient suffering from schizophrenia with predominance of positive symptoms, poorly tolerating typical neuroleptics and with no positive result of a standard dose of olanzapine treatment, was treated with high doses of olanzapine. PANSS was used to assess severity of symptoms, to rate side effects. The authors used Webels modification of Simpson and Angus scale.
RESULTS: During the high dose olanzapine treatment a marked reduction of PANSS score was achieved. Also the reduction of score in Simpson and Angus scale was observed, high level of this score at the beginning was due to classical neuroleptic treatment. There was no increase in blood prolactin level (in comparison with the high earlier one after typical neuroleptic treatment), whilst glucose level was not elevated.
CONCLUSIONS: High dose olanzapine seems to be an effective and safe method of treatment of paranoid schizophrenia with predominance of positive symptoms in patients poorly tolerating typical neuroleptics.
METHOD: The patient suffering from schizophrenia with predominance of positive symptoms, poorly tolerating typical neuroleptics and with no positive result of a standard dose of olanzapine treatment, was treated with high doses of olanzapine. PANSS was used to assess severity of symptoms, to rate side effects. The authors used Webels modification of Simpson and Angus scale.
RESULTS: During the high dose olanzapine treatment a marked reduction of PANSS score was achieved. Also the reduction of score in Simpson and Angus scale was observed, high level of this score at the beginning was due to classical neuroleptic treatment. There was no increase in blood prolactin level (in comparison with the high earlier one after typical neuroleptic treatment), whilst glucose level was not elevated.
CONCLUSIONS: High dose olanzapine seems to be an effective and safe method of treatment of paranoid schizophrenia with predominance of positive symptoms in patients poorly tolerating typical neuroleptics.