Wei sheng yan jiu = Journal of hygiene research · 2013
[Meta-analysis of the association between adiponectin gene +276g/T polymorphisms and coronary atherosclerotic heart disease].
СтатьяМетаанализНазвание и аннотация: Перевод в очереди
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Zhang Zaiwei, Tian Hongyan, Zhao Yaling, Ma Aiqun, Lu Qun, Han Junli, Liu Ya, Tian Hua
Аннотация
OBJECTIVE: systemically evaluate the association between +276G/T single nucleotide polymorphisms of adiponectin gene and coronary atherosclerotic heart disease in Chinese population.
METHODS: 8 case-control studies about +276G/T polymorphism that were based on our inclusion criterion and available in the literature were reviewed. Meta analysis was carried out by Review Manager 4.2 software.
RESULTS: Results from Metaanalysis demonstrated no significant heterogeneity among the studies about +276G/T polymorphisms and showed significant association between the +276G/T polymorphism and coronary disease in the Chinese population, and the fixed effects OR of the allele +276G to susceptibility of the disease was (OR = 1.93, 95% CI 1.32-2.82, P = 0.0007).
CONCLUSION: The current paper on Meta-analysis demonstrated a correlation between the +276G/T single nucleotide polymorphism and the cononary disease in Chinese population.
METHODS: 8 case-control studies about +276G/T polymorphism that were based on our inclusion criterion and available in the literature were reviewed. Meta analysis was carried out by Review Manager 4.2 software.
RESULTS: Results from Metaanalysis demonstrated no significant heterogeneity among the studies about +276G/T polymorphisms and showed significant association between the +276G/T polymorphism and coronary disease in the Chinese population, and the fixed effects OR of the allele +276G to susceptibility of the disease was (OR = 1.93, 95% CI 1.32-2.82, P = 0.0007).
CONCLUSION: The current paper on Meta-analysis demonstrated a correlation between the +276G/T single nucleotide polymorphism and the cononary disease in Chinese population.