[Meta-analysis of the association between adiponectin gene +276g/T polymorphisms and coronary atherosclerotic heart disease].

OBJECTIVE

systemically evaluate the association between +276G/T single nucleotide polymorphisms of adiponectin gene and coronary atherosclerotic heart disease in Chinese population.

METHODS

8 case-control studies about +276G/T polymorphism that were based on our inclusion criterion and available in the literature were reviewed. Meta analysis was carried out by Review Manager 4.2 software.

RESULTS

Results from Metaanalysis demonstrated no significant heterogeneity among the studies about +276G/T polymorphisms and showed significant association between the +276G/T polymorphism and coronary disease in the Chinese population, and the fixed effects OR of the allele +276G to susceptibility of the disease was (OR = 1.93, 95% CI 1.32-2.82, P = 0.0007).

CONCLUSION

The current paper on Meta-analysis demonstrated a correlation between the +276G/T single nucleotide polymorphism and the cononary disease in Chinese population.