Reproductive biomedicine online · 2024
Non-invasive staging of endometrial fibrosis using diffusion-weighted imaging: a feasibility study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhou Nan, Jiang Peipei, Chen Yucan, Ma Ke, Zhu Hui, Liang Huanhuan, Hu Qing, Hu Yali, Zhou Zhengyang, Zhou Kefeng
Аннотация
RESEARCH QUESTION: Can diffusion-weighted imaging (DWI) be used to stage endometrial fibrosis?
DESIGN: This prospective study included 41 healthy women, 30 patients with mild to moderate endometrial fibrosis (MMEF) and 102 patients with severe endometrial fibrosis (SEF). Endometrial thickness and DWI-related parameters, specifically the mean intensity (ADCROI and ADCVOI) and standard deviation (ADC-SDROI and ADC-SDVOI) of the endometrial apparent diffusion coefficient (ADC) values within a region of interest (ROI) on a mid-sagittal ADC map, and volume of interest (VOI) of the entire endometrium in the corpus uteri, were measured and analysed.
RESULTS: Endometrial thickness, endometrial ADCVOI and ADCROI were significantly higher in healthy women (11.7 mm, 1.31 × 10-3 mm2/s and 1.36 × 10-3 mm2/s) than MMEF patients (7.5 mm, P < 0.001; 1.23 × 10-3 mm2/s, P = 0.001; and 1.26 × 10-3 mm2/s, P = 0.003) and SEF patients (6.2 mm, 1.15 × 10-3 mm2/s and 1.23 × 10-3 mm2/s; all P < 0.001). Endometrial ADC-SDVOI and ADC-SDROI were significantly higher in SEF patients (0.24 and 0.24) than healthy women (0.16 and 0.13) and MMEF patients (0.18 and 0.16) (all P < 0.001). The degree of endometrial fibrosis was negatively correlated with endometrial thickness, endometrial ADCVOI and ADCROI (Spearman's rho = -0.662, -0.526 and -0.349) and positively correlated with endometrial ADC-SDVOI and ADC-SDROI (Spearman's rho 0.729 and 0.713) (all P < 0.001). Compared with endometrial thickness measurements, endometrial magnetic resonance imaging parameters, particularly DWI-related parameters, demonstrated excellent accuracy in distinguishing normal endometrium, MMEF and SEF (areas under the curve >0.800).
CONCLUSIONS: DWI is particularly effective for accurately staging the microstructural changes associated with endometrial fibrosis.
DESIGN: This prospective study included 41 healthy women, 30 patients with mild to moderate endometrial fibrosis (MMEF) and 102 patients with severe endometrial fibrosis (SEF). Endometrial thickness and DWI-related parameters, specifically the mean intensity (ADCROI and ADCVOI) and standard deviation (ADC-SDROI and ADC-SDVOI) of the endometrial apparent diffusion coefficient (ADC) values within a region of interest (ROI) on a mid-sagittal ADC map, and volume of interest (VOI) of the entire endometrium in the corpus uteri, were measured and analysed.
RESULTS: Endometrial thickness, endometrial ADCVOI and ADCROI were significantly higher in healthy women (11.7 mm, 1.31 × 10-3 mm2/s and 1.36 × 10-3 mm2/s) than MMEF patients (7.5 mm, P < 0.001; 1.23 × 10-3 mm2/s, P = 0.001; and 1.26 × 10-3 mm2/s, P = 0.003) and SEF patients (6.2 mm, 1.15 × 10-3 mm2/s and 1.23 × 10-3 mm2/s; all P < 0.001). Endometrial ADC-SDVOI and ADC-SDROI were significantly higher in SEF patients (0.24 and 0.24) than healthy women (0.16 and 0.13) and MMEF patients (0.18 and 0.16) (all P < 0.001). The degree of endometrial fibrosis was negatively correlated with endometrial thickness, endometrial ADCVOI and ADCROI (Spearman's rho = -0.662, -0.526 and -0.349) and positively correlated with endometrial ADC-SDVOI and ADC-SDROI (Spearman's rho 0.729 and 0.713) (all P < 0.001). Compared with endometrial thickness measurements, endometrial magnetic resonance imaging parameters, particularly DWI-related parameters, demonstrated excellent accuracy in distinguishing normal endometrium, MMEF and SEF (areas under the curve >0.800).
CONCLUSIONS: DWI is particularly effective for accurately staging the microstructural changes associated with endometrial fibrosis.