Research priorities for cancers of the oesophagus and stomach: recommendations from a UK and Ireland patient and healthcare professional partnership exercise.
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Jones Christopher M, Ng Wee Han, Tincknell Laura, McClurg Dylan P, Adam Emily, Bhandari Pradeep, Campbell Karen, Chambers Pinkie, Ciccarelli Francesca, Coleman Helen G, Crosby Tom, Doyle Carmel, Dunn Jason M, Elliott Jessie, Fitzgerald Rebecca C, Foley Kieran G, Goh Vicky, Grabsch Heike I, Graham Trevor A, Grocott Mike, Gwynne Sarah, Harvey Jo, Jansen Marnix, Lagergren Pernilla, Lamb Claire, Leigh-Doyle Lauren, Malik Farida, Mayland Catriona, McCord Mimi, Moss Alan, Mukherjee Somnath, Petty Russell, Rananaware Siddharth, Reid Joanne, Rubin Gregory, Smyth Elizabeth, Trudgill Nigel J, Turkington Richard C, Underwood Timothy J, Walter Fiona M, Williams Jessica, Peters Christopher J
Аннотация
OBJECTIVE: We undertook a comprehensive analysis of UK and Ireland patient and healthcare professional (HCP) priorities for research into oesophagogastric cancers across the domains of prevention, diagnosis and staging, treatment, palliative care and survivorship.
DESIGN: A scoping exercise sourced research questions from patients and HCPs. These were consolidated and then confirmed by systematic review to represent a true research uncertainty. Research questions were scored on potential impact by an interdisciplinary group of HCPs and prioritised using a weighting derived from a patient survey.
RESULTS: There were 835 (395 HCP, 440 patient) respondents to the scoping (n=455) and prioritisation (n=380) surveys. Across these, 4295 suggested research uncertainties were consolidated to 92 uncertainties that were prioritised. HCP respondents represented 25 professional groups from community and hospital settings. Patient weighting changed 22.2-46.3% of priority rankings established by HCPs. All domains were represented by the 20 highest priority questions, 5 of which focused on personalising and optimally combining treatment modalities. Two other key themes related to optimising nutrition and improving quality of life during and after treatment, including in patients not cured of their cancer.
CONCLUSION: This work highlights the impact of patient input on HCP-ranked research priorities and provides a robust list of priorities to guide funders, policymakers and researchers to support and undertake impactful research.