Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2025
Efficacy of Two Doses of Ivermectin Tablet in Treatment of Scabies in Comparison to Once Application of 5% Permethrin Lotion - A Randomized Controlled Trial.
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Pal Debkumar, Behera Priyamadhaba, Ravichandran Mythry, Sahu Dinesh P, Sirka Chandra S, Patro Binod K, Dash Siddharth, Taywade Manish
Аннотация
BACKGROUND: Scabies may cause community outbreaks without early diagnosis and appropriate treatment. Oral ivermectin offsets some of the challenges associated with topical 5% permethrin application for treating scabies. We aimed to evaluate the efficacy of two doses of oral ivermectin (200 µg/kg) on day one and day seven compared to 5% (weight/volume [w/v]) once whole-body application of permethrin lotion in treating scabies.
MATERIALS AND METHODS: We recruited 100 participants with mild or moderate scabies and randomized them into ivermectin and permethrin arms using computer-generated sequences. Participants and their contacts in the ivermectin arm received two doses of ivermectin (200 µg/kg) on day one and day seven. Participants and their contacts in the permethrin arm received treatment with 5% (w/v) permethrin application over the whole body. The participants were followed up after 4-6 weeks of the intervention to determine the cure rate.
RESULTS: We got a similar cure rate among the scabies patients who received either ivermectin (90.70%) or permethrin (93.33%). The cure rate was 100% after one dose of whole-body application of permethrin or two appropriate doses of ivermectin among mild to moderate cases of scabies. The cost was lower in the ivermectin arm than in the permethrin arm.
CONCLUSION: The cure rates of scabies with one local application of 5% permethrin lotion and two doses of oral ivermectin tablets are similar. Ivermectin has an added advantage that the cost is lower and its usage is convenient.
MATERIALS AND METHODS: We recruited 100 participants with mild or moderate scabies and randomized them into ivermectin and permethrin arms using computer-generated sequences. Participants and their contacts in the ivermectin arm received two doses of ivermectin (200 µg/kg) on day one and day seven. Participants and their contacts in the permethrin arm received treatment with 5% (w/v) permethrin application over the whole body. The participants were followed up after 4-6 weeks of the intervention to determine the cure rate.
RESULTS: We got a similar cure rate among the scabies patients who received either ivermectin (90.70%) or permethrin (93.33%). The cure rate was 100% after one dose of whole-body application of permethrin or two appropriate doses of ivermectin among mild to moderate cases of scabies. The cost was lower in the ivermectin arm than in the permethrin arm.
CONCLUSION: The cure rates of scabies with one local application of 5% permethrin lotion and two doses of oral ivermectin tablets are similar. Ivermectin has an added advantage that the cost is lower and its usage is convenient.