Archives of oral biology · 2026
Assessment of oxidative and inflammatory biomarkers in denture-related traumatic ulcers treated with different topical agents.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Okicic Nemanja, Milojevic Samanovic Andjela, Jovanovic Milica, Jakovljevic Vladimir, Zivkovic Vladimir, Kocovic Aleksandar, Nikolic Marina, Andjic Marijana, Lazarevic Nevena, Petrovic Anica, Stanisic Dragana, Mladenovic Rasa, Milosavljevic Marko
Аннотация
OBJECTIVE: To investigate the potential role of oxidative and inflammatory status in saliva during the healing of denture-related traumatic ulcers, applying various topical agents.
DESIGN: The prospective cohort study included 100 participants with denture-related traumatic ulcers, divided into five groups: traumatic ulcers that were not treated and treated with topical agents (0.2% hyaluronic acid gel, 0.3% hyaluronic acid-taurine gel, a gel based on an herbal preparation, and panthenol mouthwash) for seven days. Unstimulated saliva samples were collected. Oxidative stress parameters were determined spectrophotometrically. Inflammatory markers and vascular endothelial growth factor (VEGF) were analyzed using an enzyme-linked immunosorbent assay. Data were analysed by Kruskal-Wallis and Mann-Whitney U test (P < 0.05).
RESULTS: The values of superoxide anion radical, index of lipid peroxidation, and hydrogen peroxide were significantly decreased in groups that used gels based on hyaluronic acid or hyaluronic acid-taurine compared to other groups (P < 0.05); conversely, superoxide dismutase, catalase, and reduced glutathione were significantly increased (P < 0.05). The levels of interleukin-6, interleukin-17, and tumor necrosis factor alpha were significantly decreased (P < 0.05), while the levels of interleukin-10 and VEGF were significantly increased in the hyaluronic acid or hyaluronic acid-taurine groups in comparison to other treatments (P < 0.05).
CONCLUSION: Hyaluronic acid or hyaluronic acid-taurine gels were associated with pronounced changes in salivary biomarkers, reflecting improvements in redox status, inflammation balance, and angiogenesis. The current research may help clarify the potential molecular mechanisms influencing the healing of traumatic ulcers after the placement of new removable dentures using various topical agents, with due consideration of study limitations.
DESIGN: The prospective cohort study included 100 participants with denture-related traumatic ulcers, divided into five groups: traumatic ulcers that were not treated and treated with topical agents (0.2% hyaluronic acid gel, 0.3% hyaluronic acid-taurine gel, a gel based on an herbal preparation, and panthenol mouthwash) for seven days. Unstimulated saliva samples were collected. Oxidative stress parameters were determined spectrophotometrically. Inflammatory markers and vascular endothelial growth factor (VEGF) were analyzed using an enzyme-linked immunosorbent assay. Data were analysed by Kruskal-Wallis and Mann-Whitney U test (P < 0.05).
RESULTS: The values of superoxide anion radical, index of lipid peroxidation, and hydrogen peroxide were significantly decreased in groups that used gels based on hyaluronic acid or hyaluronic acid-taurine compared to other groups (P < 0.05); conversely, superoxide dismutase, catalase, and reduced glutathione were significantly increased (P < 0.05). The levels of interleukin-6, interleukin-17, and tumor necrosis factor alpha were significantly decreased (P < 0.05), while the levels of interleukin-10 and VEGF were significantly increased in the hyaluronic acid or hyaluronic acid-taurine groups in comparison to other treatments (P < 0.05).
CONCLUSION: Hyaluronic acid or hyaluronic acid-taurine gels were associated with pronounced changes in salivary biomarkers, reflecting improvements in redox status, inflammation balance, and angiogenesis. The current research may help clarify the potential molecular mechanisms influencing the healing of traumatic ulcers after the placement of new removable dentures using various topical agents, with due consideration of study limitations.
Предметные рубрики MeSH
HumansOxidative StressBiomarkersHyaluronic AcidVascular Endothelial Growth Factor AFemaleProspective StudiesMaleAdministration, TopicalSalivaTaurineOral UlcerDenturesEnzyme-Linked Immunosorbent AssayWound HealingTumor Necrosis Factor-alphaSuperoxide DismutaseLipid PeroxidationCatalaseHydrogen PeroxideSuperoxidesGlutathionePantothenic Acid