Hydroquinone and Emerging Depigmenting Agents: Clinical Guidelines, Regulatory History, and Global Safety Considerations.

Hydroquinone has long served as the gold standard for hyperpigmentation treatment, but safety concerns, regulatory changes, and growing interest in non-hydroquinone therapies have prompted reevaluation of its role in dermatology. This review outlines the clinical use, safety profile, and evolving regulations surrounding hydroquinone, as well as emerging alternatives and combination therapies. We aim to offer an updated review on best practices for depigmenting treatment protocols and highlight ongoing debates on dermatologic safety and efficacy. &nbsp.