Zhonghua yi xue za zhi · 2009
[Clinical significance on atypical cervical glandular cytology].
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Wang Qiu-Xi, Wang Shu-Zhen, Liu Jun
Аннотация
OBJECTIVE: To determine the pathological features and clinical implications of atypical glandular cells of undetermined significance (AGC) in cervical cytological results.
METHODS: All 87 cases of cervical cytological examinations with AGC were identified by a computerized database in our patient population. The authors analyzed the cervical histopathological results by colposcopic biopsy, dilatation and curettage (D&C), cervical loop electrosurgical excision procedure (LEEP)and follow-ups.
RESULTS: (1) Thirty-five cases (40.23%) had cervical and endometrial neoplasic findings: ten glandular lesions (11.49%) and squamous lesion was present in 25 patients (28.74%). (2) Among 61 patients with Pap smears subclassified as "AGC-not otherwise specified", there were 18 pathological abnormalities. Sixteen patients with AGC as "favor intraepithelial neoplasia" were of 9 pathological abnormalities. Ten patients with AGC as "adenocarcinoma in situ" or "adenocarcinoma" were of 6 pathological abnormalities. (3) 100% of patients with AGC had both of colposcopic and cytologic follow-ups: 1 case CIN1, 1 case CIN2 and 1 case CIN3. (4) One of 10 patients was younger than 35 years old with CGIN1 and the other 9 patient aged over 35 years old had a greater diversity of glandular lesions.
CONCLUSION: A finding of AGC requires both colposcopy and an aggressive workup because of a high rate of cancer and precancerous lesions. The onset of disease is age-related. Women aged over 35 years old has a greater diversity of glandular lesions and account for most cases of cervical and endometrial adenocarcinoma.
METHODS: All 87 cases of cervical cytological examinations with AGC were identified by a computerized database in our patient population. The authors analyzed the cervical histopathological results by colposcopic biopsy, dilatation and curettage (D&C), cervical loop electrosurgical excision procedure (LEEP)and follow-ups.
RESULTS: (1) Thirty-five cases (40.23%) had cervical and endometrial neoplasic findings: ten glandular lesions (11.49%) and squamous lesion was present in 25 patients (28.74%). (2) Among 61 patients with Pap smears subclassified as "AGC-not otherwise specified", there were 18 pathological abnormalities. Sixteen patients with AGC as "favor intraepithelial neoplasia" were of 9 pathological abnormalities. Ten patients with AGC as "adenocarcinoma in situ" or "adenocarcinoma" were of 6 pathological abnormalities. (3) 100% of patients with AGC had both of colposcopic and cytologic follow-ups: 1 case CIN1, 1 case CIN2 and 1 case CIN3. (4) One of 10 patients was younger than 35 years old with CGIN1 and the other 9 patient aged over 35 years old had a greater diversity of glandular lesions.
CONCLUSION: A finding of AGC requires both colposcopy and an aggressive workup because of a high rate of cancer and precancerous lesions. The onset of disease is age-related. Women aged over 35 years old has a greater diversity of glandular lesions and account for most cases of cervical and endometrial adenocarcinoma.