Research square · 2026
Impact of Alcohol Use Discontinuation on Adipose Tissue Insulin Resistance Among Latino Patients With and Without Underlying Chronic Liver Disease.
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Patel Shyam, Do Albert, Shui Amy, Khalili Mandana
Аннотация
INTRODUCTION: We evaluated the effect of short-term moderate alcohol discontinuation on adipose tissue insulin resistance (adipo-IR) and factors associated with its change in Latinos with and without hepatitis C virus (HCV).
METHODS: Nondiabetic Latino adults without (N = 17) or with (N = 7) HCV underwent clinical, laboratory, genetic, and metabolic testing. Metabolic testing was repeated after 6.5 weeks of moderate alcohol discontinuation. Adipo-IR was measured using a 2-step insulin suppression test. Multivariable linear regression, including HCV status, identified factors associated with change in adipo-IR.
RESULTS: Median age was 50 years, 58% female, median BMI 26.3 kg/m2. Genetic ancestry was 57% European, 36% Native American, and 3.5% African. CYP2E1 genotyping showed 14% were homozygous for [c2/c2] risk-allele. No significant changes in adipo-IR occurred after alcohol discontinuation. On multivariable regression, CYP2E1 homozygous risk-allele (vs. none, estimate 0.25 mmol/L, p < 0.001) and overweight/obesity (vs. normal weight, estimate 0.13 mmol/L, p = 0.02), but not HCV, were associated with change in adipo-IR following alcohol discontinuation.
CONCLUSIONS: The effect of moderate alcohol cessation on adipo-IR is modulated by obesity and CYP2E1 homozygous risk-allele in Latinos, independent of HCV status. Alongside HCV eradication, alcohol cessation and weight loss are important for populations with CYP2E1 polymorphism to prevent adverse outcomes of insulin resistance.
METHODS: Nondiabetic Latino adults without (N = 17) or with (N = 7) HCV underwent clinical, laboratory, genetic, and metabolic testing. Metabolic testing was repeated after 6.5 weeks of moderate alcohol discontinuation. Adipo-IR was measured using a 2-step insulin suppression test. Multivariable linear regression, including HCV status, identified factors associated with change in adipo-IR.
RESULTS: Median age was 50 years, 58% female, median BMI 26.3 kg/m2. Genetic ancestry was 57% European, 36% Native American, and 3.5% African. CYP2E1 genotyping showed 14% were homozygous for [c2/c2] risk-allele. No significant changes in adipo-IR occurred after alcohol discontinuation. On multivariable regression, CYP2E1 homozygous risk-allele (vs. none, estimate 0.25 mmol/L, p < 0.001) and overweight/obesity (vs. normal weight, estimate 0.13 mmol/L, p = 0.02), but not HCV, were associated with change in adipo-IR following alcohol discontinuation.
CONCLUSIONS: The effect of moderate alcohol cessation on adipo-IR is modulated by obesity and CYP2E1 homozygous risk-allele in Latinos, independent of HCV status. Alongside HCV eradication, alcohol cessation and weight loss are important for populations with CYP2E1 polymorphism to prevent adverse outcomes of insulin resistance.