Association of systemic inflammatory response index with serum uric acid levels, hyperuricemia, and gout in adults aged 20 years and older in the United States: A cross-sectional study.

This study aimed to explore the association between the systemic inflammatory response index (SIRI) and the prevalence of gout, hyperuricemia, and serum uric acid (SUA) levels with the help of the National health and nutrition examination survey database. This study analyzed the association of SIRI with SUA levels, hyperuricemia, and gout using National health and nutrition examination survey data for the period 2007 to 2018. We applied smoothed curve fitting to confirm the nonlinear correlation between SIRI and the above indicators and further verified this relationship through threshold effect analysis. In addition, we applied receiver operating characteristic curve analysis to evaluate the validity of SIRI in the diagnosis of hyperuricemia and gout. Including 29,929 adults aged 20 and older, the study found significant positive correlations between SIRI and SUA levels, hyperuricemia, and gout after adjusting for potential confounders. These correlations were consistent in gender-stratified subgroup analyses. Threshold effect analysis revealed an inflection point for SIRI at 1.508 (1000 cells/µL) for gout and 0.529 (1000 cells/µL) for hyperuricemia, with significant positive associations observed up to these points. Receiver operating characteristic analysis confirmed SIRI's diagnostic value for hyperuricemia (area under the curve = 0.5534) and gout (area under the curve = 0.6041). Association between SIRI and SUA levels, prevalence of gout and hyperuricemia. Our study reveals SIRI as an emerging, validated, and convenient composite inflammatory index that may serve as a new indicator for assessing gout and hyperuricemia disease activity in U.S. adults aged 20 years and older.