Lasers in surgery and medicine · 2025
Successful Treatment of Recalcitrant Extragenital Lichen Sclerosus With Fractional CO2 Laser and Platelet-Rich Plasma: A Case Report With Histologic Evaluation.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Halim Paulus Anthony, Sirait Sondang P, Wibawa Larisa Paramitha, Yusharyahya Shannaz Nadia, Ling Michael Sie Shun
Аннотация
OBJECTIVE: Lichen sclerosus (LS) is a chronic inflammatory dermatosis that predominantly affects the genital region, but can also manifest in other areas of the body. Extragenital LS is often less responsive to standard treatments, necessitating alternative modalities. Herein, we describe the case of a young adult man with a 7-year history of an enlarging sclerotic plaque on the right thigh, refractory to high-potency topical corticosteroids and intralesional triamcinolone.
METHODS: The patient underwent three sessions of fractional CO2 laser combined with platelet-rich plasma (PRP) therapy over 6 months. Pre- and post-treatment biopsies were performed to investigate histologic changes associated with the healing response.
RESULTS: The treatment resulted in near-complete flattening of the plaque and resolution of dermal sclerosis. A post-treatment biopsy confirmed diminished collagen hyalinization, restoration of elastic fibers, and increased fibroblasts and neovascularization. No recurrence was observed at 1-year follow-up.
CONCLUSION: This case highlights the potential role of fractional CO2 laser combined with PRP as an effective therapeutic option for recalcitrant extragenital LS. Further studies are warranted to validate this combined approach.
METHODS: The patient underwent three sessions of fractional CO2 laser combined with platelet-rich plasma (PRP) therapy over 6 months. Pre- and post-treatment biopsies were performed to investigate histologic changes associated with the healing response.
RESULTS: The treatment resulted in near-complete flattening of the plaque and resolution of dermal sclerosis. A post-treatment biopsy confirmed diminished collagen hyalinization, restoration of elastic fibers, and increased fibroblasts and neovascularization. No recurrence was observed at 1-year follow-up.
CONCLUSION: This case highlights the potential role of fractional CO2 laser combined with PRP as an effective therapeutic option for recalcitrant extragenital LS. Further studies are warranted to validate this combined approach.