Impact of Sex on Residual Angina After Percutaneous Coronary Interventions.
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Hada Masahiro, Mizukami Takuya, Ikeda Kazumasa, Munhoz Daniel, Brouwers Sofie, Sonck Jeroen, Matsuo Hitoshi, Shinke Toshiro, Ando Hirohiko, Ko Brian, Biscaglia Simone, Rivero Fernando, Engstrøm Thomas, Arslani Ketina, Leone Antonio Maria, Galante Domenico, van Nunen Lokien X, Fearon William F, Christiansen Evald Høj, Fournier Stephane, Desta Liyew, Yong Andy, Adjedj Julien, Escaned Javier, Nakayama Masafumi, Eftekhari Ashkan, Zimmermann Frederik M, Sakai Koshiro, Storozhenko Tatyana, da Costa Bruno R, Campo Gianluca, Berry Colin, Collison Damien, Johnson Thomas, Amano Tetsuya, Perera Divaka, Jeremias Allen, Ali Ziad, De Bruyne Bernard, Barbato Paola, Corradetti Sara, Stalikas Nikolaos, Kechichian Anthony, Bouisset Frederic, Kakuta Tsunekazu, Johnson Nils P, Collet Carlos
Аннотация
OBJECTIVES: To evaluate the influence of sex on residual angina at one year after percutaneous coronary intervention (PCI), stratified by PPG.
METHODS: We performed a sub-analysis of PPG Global, a multicenter, prospective, single-arm study. All patients had hemodynamically significant CAD (fractional flow reserve [FFR] ≤ 0.80) and underwent a manual FFR pullbacks to calculate PPG before PCI. Patient-reported outcomes were collected using the 7-item Seattle Angina Questionnaire (SAQ-7) at baseline and 1-year follow-up.
RESULTS: We included 814 patients (205 [25.2%] women and 609 [74.8%] men). Women were significantly older than men (70 ± 10 years vs. 67 ± 10 years p < 0.001). Baseline FFR were comparable between sexes (0.68 ± 0.13 vs. 0.66 ± 0.12, p = 0.098), but women had a more focal CAD compared to men (PPG 0.66 ± 0.15 vs. 0.63 ± 0.15, p = 0.047). Post PCI-FFR was higher in women than men (0.88 ± 0.07 vs. 0.87 ± 0.07, p = 0.041); however, angina at 1 year was more frequent in women (SAQ angina frequency score 94 ± 12 vs. 96 ± 10, p = 0.041).
CONCLUSION: Despite having a more focal CAD pattern and achieving higher post-PCI FFR, women report more residual angina than men at 1-year follow-up.
TRIAL REGISTRATION: ClinicalTrials.gov NCT04789317.