Current drug delivery · 2026
Adapalene in Acne Treatment: Innovations in Nanocarriers and Role of AI in Drug Delivery- A Comprehensive Review.
СтатьяНазвание и аннотация: Перевод в очереди
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Verma Tushar, Singh Ravi Pratap, Chaudhary Mahima, Sharma Pramod Kumar, Kumar Dharmendra
Аннотация
INTRODUCTION: Acne vulgaris is a prevalent dermatological disorder that affects millions worldwide, causing both physical discomfort and psychological burden. Conventional therapies often provide limited benefit due to poor skin permeability and tolerability issues.
METHODS: This study covers indepth literature study (2000-2025) on Adapalene in acne treatment. Closely related 150 studies on innovative nanocarriers and the role of AI in Drug Delivery were included, while unrelated works were excluded.
RESULTS: Although adapalene demonstrates strong anti-acne activity, its limited membrane permeability and local dermatological adverse reactions restrict clinical effectiveness. Nanocarrier-based systems resolved these issues by enhancing drug penetration and controlled release, as evidenced by case studies and major clinical trials. ANN-assisted optimization further refined drug delivery, enabling more effective and personalized management of acne.
DISCUSSION: Adapalene is a promising therapeutic agent for acne vulgaris; however, its limited pharmacokinetic profile restricts its effectiveness. The integration of nanotechnology and AI-driven optimization could significantly improve its therapeutic potential, a concept further supported by findings from various clinical studies.
CONCLUSION: Adapalene-loaded nanocarriers represent a promising approach for improving therapeutic outcomes in acne treatment. Integration of AI-based optimization with clinical validation highlights its translational potential, paving the way toward safer, more efficient, and patient-specific dermatological therapies.
METHODS: This study covers indepth literature study (2000-2025) on Adapalene in acne treatment. Closely related 150 studies on innovative nanocarriers and the role of AI in Drug Delivery were included, while unrelated works were excluded.
RESULTS: Although adapalene demonstrates strong anti-acne activity, its limited membrane permeability and local dermatological adverse reactions restrict clinical effectiveness. Nanocarrier-based systems resolved these issues by enhancing drug penetration and controlled release, as evidenced by case studies and major clinical trials. ANN-assisted optimization further refined drug delivery, enabling more effective and personalized management of acne.
DISCUSSION: Adapalene is a promising therapeutic agent for acne vulgaris; however, its limited pharmacokinetic profile restricts its effectiveness. The integration of nanotechnology and AI-driven optimization could significantly improve its therapeutic potential, a concept further supported by findings from various clinical studies.
CONCLUSION: Adapalene-loaded nanocarriers represent a promising approach for improving therapeutic outcomes in acne treatment. Integration of AI-based optimization with clinical validation highlights its translational potential, paving the way toward safer, more efficient, and patient-specific dermatological therapies.