Medicina clinica · 2025
Association of anti-CarP levels with clinical activity and serological profile in rheumatoid arthritis.
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Martínez Calabuig Pablo, Grau García Elena, Román Ivorra José Andrés
Аннотация
OBJECTIVE: To analyze the association of anti-CarP levels with clinical activity, manifestations, and serological profile in rheumatoid arthritis (RA) patients.
METHODS: Cross-sectional study including RA patients and healthy controls (HC). Clinical and analytical data were collected, and anti-CarP levels were measured by ELISA.
RESULTS: A total of 101 patients (79% female, mean age 45), and 98 HC (67% female, mean age 55) were included. RA patients had significantly higher anti-CarP levels than HC (p<0.001), increasing with age (p=0.004). Anti-CarP correlated with RF and ACPA positivity (p<0.001). Those patients with RF/ACPA positive showed the highest anti-CarP levels compared to other groups (p<0.001). The threshold for elevated anti-CarP was set at 17.2ng/mL. Among 35 patients with elevated anti-CarP, 32 were RF/ACPA double-positive (p=0.006), and 3 were seronegative. Elevated anti-CarP levels were associated to clinical activity, tender joints (p=0.002), the presence of rheumatoid nodules and interstitial lung disease, but not with Sharp/van der Heijde score, joint damage progression or Sjögren syndrome.
CONCLUSIONS: RA patients exhibit higher anti-CarP levels, especially those with RF/ACPA double-positivity. Elevated levels correlate with higher disease activity and extra-articular involvement.
METHODS: Cross-sectional study including RA patients and healthy controls (HC). Clinical and analytical data were collected, and anti-CarP levels were measured by ELISA.
RESULTS: A total of 101 patients (79% female, mean age 45), and 98 HC (67% female, mean age 55) were included. RA patients had significantly higher anti-CarP levels than HC (p<0.001), increasing with age (p=0.004). Anti-CarP correlated with RF and ACPA positivity (p<0.001). Those patients with RF/ACPA positive showed the highest anti-CarP levels compared to other groups (p<0.001). The threshold for elevated anti-CarP was set at 17.2ng/mL. Among 35 patients with elevated anti-CarP, 32 were RF/ACPA double-positive (p=0.006), and 3 were seronegative. Elevated anti-CarP levels were associated to clinical activity, tender joints (p=0.002), the presence of rheumatoid nodules and interstitial lung disease, but not with Sharp/van der Heijde score, joint damage progression or Sjögren syndrome.
CONCLUSIONS: RA patients exhibit higher anti-CarP levels, especially those with RF/ACPA double-positivity. Elevated levels correlate with higher disease activity and extra-articular involvement.