Surgical neurology international · 2026
Successful intravenous alteplase for acute ischemic stroke secondary to radiation-induced intracranial arterial stenosis in a child: An illustrative case.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Mitsui Takahito, Kurokawa Toru, Suzuki Kohei, Yamamoto Junkoh, Tanaka Yuko
Аннотация
BACKGROUND: Delayed cerebrovascular complications after radiotherapy have been well-documented. However, optimal management of acute ischemic stroke secondary to radiation-induced intracranial arterial stenosis remains unclear.
CASE DESCRIPTION: A 17-year-old girl developed an acute ischemic stroke secondary to delayed middle cerebral artery stenosis following radiotherapy for recurrent craniopharyngioma after tumor resection. Intravenous alteplase (rt-PA) was administered 4 h after symptom onset, resulting in neurological improvement, and she was discharged with a modified Rankin Scale score of 0.
CONCLUSION: This case suggests that rt-PA may be an effective treatment option for acute ischemic stroke associated with post-radiotherapy arterial stenosis, provided that the standard eligibility criteria are met.
CASE DESCRIPTION: A 17-year-old girl developed an acute ischemic stroke secondary to delayed middle cerebral artery stenosis following radiotherapy for recurrent craniopharyngioma after tumor resection. Intravenous alteplase (rt-PA) was administered 4 h after symptom onset, resulting in neurological improvement, and she was discharged with a modified Rankin Scale score of 0.
CONCLUSION: This case suggests that rt-PA may be an effective treatment option for acute ischemic stroke associated with post-radiotherapy arterial stenosis, provided that the standard eligibility criteria are met.