Frontiers in neurology · 2026
In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mansouri Hamid, Gulkaya Nedim, Gounis Matthew J, AlMajali Mohammad, Chaudhari Amit, Ramirez Abreu Darwin G, Zaidi Syed F, Ashouri Yazan K, Kaneko Naoki, Jankowitz Brian T, Altschul David J, Pabon Boris, Bhogal Pervinder, Wolfe Thomas J, Pereira Edgard L, Badruddin Aamir, Ibrahim Laila, Amili Omid, Zaidat Osama O
Аннотация
BACKGROUND: Intrasaccular devices such as SEAL™ and WEB™-SL are designed to disrupt aneurysmal flow. We present a new in vitro method for estimating neurointerventional devices' flow dynamics.
METHODS: Particle image velocimetry (PIV) method was used in a patient-specific middle cerebral artery (MCA) wide-neck bifurcation aneurysm (WNBA) model to measure velocity, residence time (RT), and vorticity strength (VS). Tested devices included 3 each of SEAL-BASE (6 × 2 mm), SEAL-ARC (6 × 5 mm), and WEB-SL (6 × 4 mm).
RESULTS: Twelve experiments were performed (3 unique devices per size and 3 controls); the mean RT was 0.042 ± 0.006 s (control) and increased with SEAL-BASE (0.387 ± 0.128), SEAL-ARC (0.33 ± 0.092), and WEB-SL (0.171 ± 0.034) (all p < 0.05 vs. control), and was longer in SEAL-BASE (p = 0.046) and SEAL-ARC (p = 0.041) than WEB-SL, with no difference between SEAL configurations (p = 0.30). The VS decreased from 66.48 ± 8.58 1/s (control) to 14.06 ± 2.80, 13.94 ± 2.53, and 27.60 ± 4.16 for SEAL-BASE, SEAL-ARC, and WEB-SL, respectively. The SEAL devices differed from WEB-SL (p = 0.007, 0.006) but not from each other (p = 0.52). Velocity magnitude dropped from 109.4 ± 15.5 mm/s (control) to 12.42 ± 3.8, 14.2 ± 3.5, and 25.34 ± 3.16 for SEAL-BASE, SEAL-ARC, and WEB-SL, respectively; greater reductions with SEAL-BASE (p = 0.006) and SEAL-ARC (p = 0.007) versus WEB-SL, with no difference between the two SEAL configurations (p = 0.29).
CONCLUSION: Both SEAL configurations achieved greater flow reduction compared to the WEB-SL of similar width in the same aneurysm model. Results highlight the unique utilization of the PIV method for the mechanistic decoupling of momentum transfer into the aneurysm sac resulting from intra-aneurysmal mesh structures and point toward their potential for further neurointerventional device optimization.
METHODS: Particle image velocimetry (PIV) method was used in a patient-specific middle cerebral artery (MCA) wide-neck bifurcation aneurysm (WNBA) model to measure velocity, residence time (RT), and vorticity strength (VS). Tested devices included 3 each of SEAL-BASE (6 × 2 mm), SEAL-ARC (6 × 5 mm), and WEB-SL (6 × 4 mm).
RESULTS: Twelve experiments were performed (3 unique devices per size and 3 controls); the mean RT was 0.042 ± 0.006 s (control) and increased with SEAL-BASE (0.387 ± 0.128), SEAL-ARC (0.33 ± 0.092), and WEB-SL (0.171 ± 0.034) (all p < 0.05 vs. control), and was longer in SEAL-BASE (p = 0.046) and SEAL-ARC (p = 0.041) than WEB-SL, with no difference between SEAL configurations (p = 0.30). The VS decreased from 66.48 ± 8.58 1/s (control) to 14.06 ± 2.80, 13.94 ± 2.53, and 27.60 ± 4.16 for SEAL-BASE, SEAL-ARC, and WEB-SL, respectively. The SEAL devices differed from WEB-SL (p = 0.007, 0.006) but not from each other (p = 0.52). Velocity magnitude dropped from 109.4 ± 15.5 mm/s (control) to 12.42 ± 3.8, 14.2 ± 3.5, and 25.34 ± 3.16 for SEAL-BASE, SEAL-ARC, and WEB-SL, respectively; greater reductions with SEAL-BASE (p = 0.006) and SEAL-ARC (p = 0.007) versus WEB-SL, with no difference between the two SEAL configurations (p = 0.29).
CONCLUSION: Both SEAL configurations achieved greater flow reduction compared to the WEB-SL of similar width in the same aneurysm model. Results highlight the unique utilization of the PIV method for the mechanistic decoupling of momentum transfer into the aneurysm sac resulting from intra-aneurysmal mesh structures and point toward their potential for further neurointerventional device optimization.