BMC nutrition · 2025
Association of the dietary anti-oxidant index with inflammatory marker such as interleukin-6 in women with and without polycystic ovarian syndrome: a comparative case‒control study.
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Azarbayjani Khadijeh, Sadatmahalleh Shahideh Jahanian, Mottaghi Azadeh, Nasiri Malihe
Аннотация
BACKGROUND: Although the main cause of polycystic ovarian syndrome (PCOS) is still unknown, diet plays a significant role in the pathophysiology of PCOS, possibly through effects on the inflammatory response and oxidative stress pathways in the body.
METHOD: The present study was conducted as a case‒control study on 45 women with PCOS and 40 healthy women in the control group between May 2021 and February 2022 in Robat Karim, Iran. A food frequency questionnaire (FFQ) was completed for all participants, and the antioxidant indices of the diet were calculated via two different methods: ferric reducing ability of plasma (FRAP) and oxygen radical absorption capacity (ORAC) using the data obtained from the FFQ.
RESULTS: The antioxidant indices of the diet determined via the FRAP index were significantly lower in the women with PCOS than in the control group (4.94 ± 1.97 vs. 3.48 ± 1.77, P˂ 0.05), but no significant difference was observed between the two groups in terms of the antioxidant index of the diet based on the ORAC index (P˃ 0.05). Additionally, the antioxidant indices of the diet based on both the ORAC (R = 0.94, P˃ 0.05) and FRAP (R = 0.82, P˃ 0.05) indices were not significantly correlated with the inflammatory marker interleukin-6 (IL-6).
CONCLUSION: The present study supports the hypothesis of the importance of diet, especially food antioxidants, in the occurrence and exacerbation of PCOS, but the use of a suitable tool to determine the general antioxidant index of the diet in epidemiological studies related to diet and PCOS seems necessary.
METHOD: The present study was conducted as a case‒control study on 45 women with PCOS and 40 healthy women in the control group between May 2021 and February 2022 in Robat Karim, Iran. A food frequency questionnaire (FFQ) was completed for all participants, and the antioxidant indices of the diet were calculated via two different methods: ferric reducing ability of plasma (FRAP) and oxygen radical absorption capacity (ORAC) using the data obtained from the FFQ.
RESULTS: The antioxidant indices of the diet determined via the FRAP index were significantly lower in the women with PCOS than in the control group (4.94 ± 1.97 vs. 3.48 ± 1.77, P˂ 0.05), but no significant difference was observed between the two groups in terms of the antioxidant index of the diet based on the ORAC index (P˃ 0.05). Additionally, the antioxidant indices of the diet based on both the ORAC (R = 0.94, P˃ 0.05) and FRAP (R = 0.82, P˃ 0.05) indices were not significantly correlated with the inflammatory marker interleukin-6 (IL-6).
CONCLUSION: The present study supports the hypothesis of the importance of diet, especially food antioxidants, in the occurrence and exacerbation of PCOS, but the use of a suitable tool to determine the general antioxidant index of the diet in epidemiological studies related to diet and PCOS seems necessary.