Cross‑Cultural Validation of the Chronic Rhinosinusitis Patient-Reported Outcomes (CRS-PRO) Questionnaire in Portuguese.

Introduction Chronic rhinosinusitis (CRS) presents with different clinical patterns with variable responses to treatment. Clear criteria for specifying disease severity and assessing symptom control are lacking in the current literature. We aimed to perform a cross-cultural adaptation of the chronic rhinosinusitis patient-reported outcomes (CRS-PRO), creating a Portuguese version to use as a routine questionnaire in the evaluation of patients with CRS. Methods The CRS-PRO questionnaire was translated according to the recommendations of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) through a three-step procedure including a backward translation. Results After translation completion, the questionnaire was evaluated in 40 participants (23 men) who completed the questionnaire on two separate occasions in 1.4 minutes (SD 0.615). Twenty of them were patients with CRS (60% with polyps), and the other 20 were healthy subjects who were considered a control group. The average age of the study participants was 43 years old (SD 16). The intraclass correlation coefficient (ICC) values for the CRS with nasal polyps (CRSwNP) group ranged from 0.65 to 0.89, indicating good to excellent reliability across the 12 items. All ICC values were statistically significant (p < 0.01). Conclusion This study presents the Portuguese version of the CRS-PRO questionnaire, an adapted, validated, and well-accepted instrument for evaluating CRS symptoms in the Portuguese-speaking population.