Journal of the American Academy of Dermatology · 2025
Association of primary tumor location with all-cause and cancer-specific mortality in cutaneous malignant melanoma patients.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wei Shiyuan, Su Licong, Wu Liangzhi
Аннотация
BACKGROUND: Existing studies have reported conflicting associations between primary tumor location (PTL) and mortality in patients with cutaneous malignant melanoma (CMM).
OBJECTIVE: To evaluate the association of PTL with mortality among patients with CMM.
METHODS: This was a multicenter, retrospective study from Surveillance, Epidemiology, and End Results program from 2000 to 2021. Patients with histologically confirmed primary CMM were included.
RESULTS: Among 162,871 patients (56.4% male; 74.0% ≥ 50 years), 23.0% died during median 6.3-year follow-up (interquartile range: 2.7-10.9). The multivariate Cox model showed that head and neck [HN] site was significantly associated with increased risk of all-cause (adjusted hazard ratio [aHR]: 1.08, 95% confidence interval [CI]: 1.05-1.12) and cancer-specific mortality (aHR: 1.05, 95% CI: 1.02-1.09), but sites in upper limb/shoulder (ULS) and lower limb/hip (LLH) were significantly associated with decreased risk of all-cause (ULS: aHR: 0.91, 95% CI: 0.89-0.94; LLH: aHR: 0.89, 95% CI: 0.86-0.92) and cancer-specific mortality (ULS: aHR: 0.79, 95% CI: 0.75-0.84; LLH: aHR: 0.96, 95% CI: 0.92-1.00), compared with trunk. The associations were consistent in various subgroups and sensitivity analyses.
LIMITATIONS: Retrospective design may introduce selection bias.
CONCLUSIONS: HN site has higher risk of all-cause and cancer-specific mortality compared to the trunk site, whereas this effect is reversed at the sites of LLH and ULS.
OBJECTIVE: To evaluate the association of PTL with mortality among patients with CMM.
METHODS: This was a multicenter, retrospective study from Surveillance, Epidemiology, and End Results program from 2000 to 2021. Patients with histologically confirmed primary CMM were included.
RESULTS: Among 162,871 patients (56.4% male; 74.0% ≥ 50 years), 23.0% died during median 6.3-year follow-up (interquartile range: 2.7-10.9). The multivariate Cox model showed that head and neck [HN] site was significantly associated with increased risk of all-cause (adjusted hazard ratio [aHR]: 1.08, 95% confidence interval [CI]: 1.05-1.12) and cancer-specific mortality (aHR: 1.05, 95% CI: 1.02-1.09), but sites in upper limb/shoulder (ULS) and lower limb/hip (LLH) were significantly associated with decreased risk of all-cause (ULS: aHR: 0.91, 95% CI: 0.89-0.94; LLH: aHR: 0.89, 95% CI: 0.86-0.92) and cancer-specific mortality (ULS: aHR: 0.79, 95% CI: 0.75-0.84; LLH: aHR: 0.96, 95% CI: 0.92-1.00), compared with trunk. The associations were consistent in various subgroups and sensitivity analyses.
LIMITATIONS: Retrospective design may introduce selection bias.
CONCLUSIONS: HN site has higher risk of all-cause and cancer-specific mortality compared to the trunk site, whereas this effect is reversed at the sites of LLH and ULS.