PeerJ · 2024
Anodal transcranial direct current stimulation enhances response inhibition and attention allocation in fencers.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Dai Jiansong, Xiao Yang, Chen Gangrui, Gu Zhongke, Xu Kai
Аннотация
INTRODUCTION: Erectile dysfunction (ED) is common in men after myocardial infarction (MI) and is associated with poorer quality of life and systemic vascular disease. Previous studies have primarily relied on questionnaires, rarely including objective assessment of penile hemodynamics.
OBJECTIVES: We aimed to assess the quality of life in men with ED after MI treated with percutaneous coronary intervention (PCI), including routine assessment of penile hemodynamics using point‑of‑care resting Doppler ultrasonography.
PATIENTS AND METHODS: This observational, cross‑sectional, single‑center study included 600 men: 400 after MI treated with PCI and 200 without a history of MI/PCI (controls). ED was assessed using the 5‑item version of the International Index of Erectile Function (IIEF‑5) questionnaire, and quality of life was assessed using the 36-item Short‑Form Health Survey, version 2 (SF‑36v2) questionnaire. Echocardiography, carotid Doppler ultrasound, and resting penile Doppler ultrasound were performed. Associations were analyzed using the Spearman correlation and multivariable linear regression.
RESULTS: All patients after MI had ED. Quality of life scores were significantly lower in the MI group than in the controls globally (mean [SD] SF‑36v2 score, 121.3 [8.9] vs 134.6 [7.5]; P <0.001) and in the physical and mental components. Penile Doppler parameters differed between the groups and correlated with IIEF‑5 scores. In multivariable analysis, the strongest predictor of quality of life was erectile function (IIEF‑5), followed by left ventricular ejection fraction, body mass index, heart rate, and vascular parameters (intima‑media thickness, carotid and penile flow).
CONCLUSIONS: ED severity is a major independent determinant of the quality of life in men after MI/PCI. Penile hemodynamic parameters reflect systemic vascular burden and functional status. Integrated ED assessment that includes the IIEF‑5 questionnaire and routine resting penile Doppler ultrasound may enhance risk stratification and post‑MI care.
OBJECTIVES: We aimed to assess the quality of life in men with ED after MI treated with percutaneous coronary intervention (PCI), including routine assessment of penile hemodynamics using point‑of‑care resting Doppler ultrasonography.
PATIENTS AND METHODS: This observational, cross‑sectional, single‑center study included 600 men: 400 after MI treated with PCI and 200 without a history of MI/PCI (controls). ED was assessed using the 5‑item version of the International Index of Erectile Function (IIEF‑5) questionnaire, and quality of life was assessed using the 36-item Short‑Form Health Survey, version 2 (SF‑36v2) questionnaire. Echocardiography, carotid Doppler ultrasound, and resting penile Doppler ultrasound were performed. Associations were analyzed using the Spearman correlation and multivariable linear regression.
RESULTS: All patients after MI had ED. Quality of life scores were significantly lower in the MI group than in the controls globally (mean [SD] SF‑36v2 score, 121.3 [8.9] vs 134.6 [7.5]; P <0.001) and in the physical and mental components. Penile Doppler parameters differed between the groups and correlated with IIEF‑5 scores. In multivariable analysis, the strongest predictor of quality of life was erectile function (IIEF‑5), followed by left ventricular ejection fraction, body mass index, heart rate, and vascular parameters (intima‑media thickness, carotid and penile flow).
CONCLUSIONS: ED severity is a major independent determinant of the quality of life in men after MI/PCI. Penile hemodynamic parameters reflect systemic vascular burden and functional status. Integrated ED assessment that includes the IIEF‑5 questionnaire and routine resting penile Doppler ultrasound may enhance risk stratification and post‑MI care.