NPJ Parkinson's disease · 2025
Will adaptive deep brain stimulation for Parkinson's disease become a real option soon? A Delphi consensus study.
СтатьяНазвание и аннотация: Перевод в очереди
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Guidetti Matteo, Bocci Tommaso, De Pedro Del Álamo Marta, Deuschl Guenther, Fasano Alfonso, Martinez-Fernandez Raul, Gasca-Salas Carmen, Hamani Clement, Krauss Joachim K, Kühn Andrea A, Limousin Patricia, Little Simon, Lozano Andres M, Maiorana Natale V, Marceglia Sara, Okun Michael S, Oliveri Serena, Ostrem Jill L, Scelzo Emma, Schnitzler Alfons, Starr Philip A, Temel Yasin, Timmermann Lars, Tinkhauser Gerd, Visser-Vandewalle Veerle, Volkmann Jens, Priori Alberto
Аннотация
While conventional deep brain stimulation (cDBS) treatment delivers continuous electrical stimuli, new adaptive DBS (aDBS) technology provides dynamic symptom-related stimulation. Research data are promising, and devices are already available, but are we ready for it? We asked leading DBS experts worldwide (n = 21) to discuss a research agenda for aDBS research in the near future to allow full adoption. A 5-point Likert scale questionnaire, along with a Delphi method, was employed. In the next 10 years, aDBS will be clinical routine, but research is needed to define which patients would benefit more from the treatment; second, implantation and programming procedures should be simplified to allow actual generalized adoption; third, new adaptive algorithms, and the integration of aDBS paradigm with new technologies, will improve control of more complex symptoms. Since the next years will be crucial for aDBS implementation, the research should focus on improving precision and making programming procedures more accessible.