Annals of medicine and surgery (2012) · 2025
Rare case of ovarian Sertoli-Leydig cell tumor in an adolescent: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Junaid Ayesha, Yousuf Fizza, Zafar Rabia, Taj Javeria, Yokolo Hermann
Аннотация
INTRODUCTION AND IMPORTANCE: Androgen-producing tumors are rare in females, typically arising from the ovaries or adrenal glands. Sertoli-Leydig cell tumors (SLCTs) are uncommon sex cord-stromal ovarian tumors that cause hyperandrogenism, leading to virilization symptoms such as hirsutism, deep voice, and amenorrhea. Their rarity and similarity with other androgen-secreting conditions make diagnosis challenging. This case report describes an SLCT in a 16-year-old girl, underscoring the value of early diagnosis and fertility-sparing surgery.
CASE PRESENTATION: A 16-year-old girl presented with secondary amenorrhea, hirsutism, and voice deepening. Hormonal workup revealed elevated testosterone and low sex hormone-binding globulin. Imaging identified a solid mass in the left ovary. Adrenal causes were excluded via hormonal assays and imaging. The patient underwent a laparotomy with left salpingo-oophorectomy. Histopathology confirmed a moderately differentiated SLCT, and immunohistochemistry was positive for inhibin and calretinin. Postoperative CT showed no metastasis. She required no chemotherapy and remained under regular follow-up.
CLINICAL DISCUSSION: SLCTs represent less than 1% of ovarian tumors and primarily affect young women. They often present with signs of androgen excess. Diagnosis relies on clinical, hormonal, imaging, and histological data. DICER1 gene mutations are frequently associated. Surgical excision is the standard treatment, with fertility-sparing options preferred in early stages. Chemotherapy is reserved for advanced or poorly differentiated cases.
CONCLUSION: SLCT is a rare but treatable ovarian tumor. Early detection of androgen excess is crucial. Surgery is effective, and fertility can be preserved. Larger registries are needed to enhance disease understanding and management strategies.
CASE PRESENTATION: A 16-year-old girl presented with secondary amenorrhea, hirsutism, and voice deepening. Hormonal workup revealed elevated testosterone and low sex hormone-binding globulin. Imaging identified a solid mass in the left ovary. Adrenal causes were excluded via hormonal assays and imaging. The patient underwent a laparotomy with left salpingo-oophorectomy. Histopathology confirmed a moderately differentiated SLCT, and immunohistochemistry was positive for inhibin and calretinin. Postoperative CT showed no metastasis. She required no chemotherapy and remained under regular follow-up.
CLINICAL DISCUSSION: SLCTs represent less than 1% of ovarian tumors and primarily affect young women. They often present with signs of androgen excess. Diagnosis relies on clinical, hormonal, imaging, and histological data. DICER1 gene mutations are frequently associated. Surgical excision is the standard treatment, with fertility-sparing options preferred in early stages. Chemotherapy is reserved for advanced or poorly differentiated cases.
CONCLUSION: SLCT is a rare but treatable ovarian tumor. Early detection of androgen excess is crucial. Surgery is effective, and fertility can be preserved. Larger registries are needed to enhance disease understanding and management strategies.