Oncotarget · 2016
Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients.
СтатьяНазвание и аннотация: Перевод в очереди
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Gazon Hélène, Belrose Gildas, Terol Marie, Meniane Jean-Come, Mesnard Jean-Michel, Césaire Raymond, Peloponese Jean-Marie
Аннотация
Lateral lumbar interbody fusion (LLIF) and pedicle subtraction osteotomy are common procedures to correct adult spinal deformities. Little is known about returning postoperatively to a high-performance sport such as skiing after spinal surgery. We report a case of an alpine skier who underwent a LLIF procedure combined with a posterior corrective osteotomy and posterior instrumentation, who had difficulties returning to skiing postoperatively because of new spinal biomechanics. The case report describes the possible consequences of spinal sagittal deformity surgery on postoperative skiing. A 63-year-old man with a complex lumbar spinal surgery history showed severe adjacent segment degenerative spondylolistheses at L1-L2 and at L5-S1. A lateral approach at L1-L2 combined with a posterior corrective osteotomy at L3 and instrumentation from T10 to the pelvis were performed. At his 1-year follow up, he made excellent progress and returned to skiing. However, he reported that skiing did not feel the same, and his center of gravity felt as if it shifted backwards. Consequently, he placed a 2-cm wedge in his ski binding, which improved his skiing experience. Sagittal vertical axis changes after spinal surgery affect the biomechanics of the entire body. After surgery, the body's ligaments, muscles, and fascia adapt to the new body posture. Activities such as skiing, where body posture plays an essential role, are particularly affected by spine surgeries. Surgeons should discuss this issue before spinal surgery with patients, especially if patients are involved in high-intensity sports.
Предметные рубрики MeSH
AdultAgedAntineoplastic Combined Chemotherapy ProtocolsBasic-Leucine Zipper Transcription FactorsCD4-Positive T-LymphocytesCell Line, TumorDEAD-box RNA HelicasesFemaleGene Expression Regulation, LeukemicHEK293 CellsHTLV-I InfectionsHuman T-lymphotropic virus 1HumansJurkat CellsLeukemia-Lymphoma, Adult T-CellMaleMicroRNAsMiddle AgedPrecursor T-Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene Proteins c-junRetroviridae ProteinsRibonuclease IIIValproic Acid